Title: | Directed coordination study of [Pd(en)(H2O)2]2+ with hetero-tripeptides containing C-terminus methyl esters employing NMR spectroscopy |
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Date: | 2020-07-16 |
Language: | English |
Scope: | 811-825 |
University/Institute: | Háskóli Íslands University of Iceland |
School: | Verkfræði- og náttúruvísindasvið (HÍ) School of Engineering and Natural Sciences (UI) |
Department: | Raunvísindadeild (HÍ) Faculty of Physical Sciences (UI) Raunvísindastofnun (HÍ) Science Institute (UI) |
Series: | JBIC Journal of Biological Inorganic Chemistry;25(5) |
ISSN: | 0949-8257 1431-1327 (eISSN) |
DOI: | 10.1007/s00775-020-01804-0 |
Subject: | Efnasambönd; Efnasamsetning |
URI: | https://hdl.handle.net/20.500.11815/1976 |
Citation:Monger, L.J., Runarsdottir, G.R. & Suman, S.G. Directed coordination study of [Pd(en)(H2O)2]2+ with hetero-tripeptides containing C-terminus methyl esters employing NMR spectroscopy. J Biol Inorg Chem 25, 811–825 (2020). https://doi.org/10.1007/s00775-020-01804-0
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Abstract:Alkylation of the C-terminus acids in small peptides allows direction to amine and amide coordination, while changing the peptide composition to form tetradentate κ4[n,5,5], where n = 5-, 6-, 7-, or 8-membered ring coordination geometries, can be achieved. The alkylated tripeptide ligands, TrpAlaGly(OMe), β-Asp(OtBu)AlaGly(OMe), Asp(OtBu)AlaGly(OMe), and the fully methylated GSH, γ-Glu(OMe)Cys(SMe)Gly(OMe), were synthesized and their coordination properties to [Pd(en)(H2O)2]2+ were studied. pH-dependent coordination was analyzed by NMR spectroscopy and the coordination to the alkylated tripeptides at selected pH values inferred from their NMR spectra. If selective coordination of amine/amide donors results in metal complexation, allowing for flexible and adjustable ligand frameworks, then this strategy could potentially be extended to other metal ions and peptide system.
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Description:Post- print / Lokaútgáfa höfundar
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