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Cytotoxicity studies of water soluble coordination compounds with a [Mo 2 O 2 S 2 ] 2+ core

Cytotoxicity studies of water soluble coordination compounds with a [Mo 2 O 2 S 2 ] 2+ core

Title: Cytotoxicity studies of water soluble coordination compounds with a [Mo 2 O 2 S 2 ] 2+ core
Author: Grétarsdóttir, Jóhanna M.
Bobersky, Sandra
Metzler-Nolte, Nils
Suman, Sigridur G   orcid.org/0000-0003-4283-6140
Date: 2016-07
Language: English
Scope: 166-171
University/Institute: Háskóli Íslands
University of Iceland
School: Verkfræði- og náttúruvísindasvið (HÍ)
School of Engineering and Natural Sciences (UI)
Department: Raunvísindadeild (HÍ)
Faculty of Physical Sciences (UI)
Series: Journal of Inorganic Biochemistry;160
ISSN: 0162-0134
DOI: 10.1016/j.jinorgbio.2016.01.020
Subject: Eiturefnafræði; Brennisteinn; Cytotoxicity; Molybdenum; Sulfur
URI: https://hdl.handle.net/20.500.11815/1948

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Citation:

Gretarsdóttir, J. M., Bobersky, S., Metzler-Nolte, N., & Suman, S. G. (2016). Cytotoxicity studies of water soluble coordination compounds with a [Mo2O2S2]2+ core. Journal of Inorganic Biochemistry, 160, 166-171. doi:https://doi.org/10.1016/j.jinorgbio.2016.01.020

Abstract:

Selected molybdenum sulfur compounds with the formulas (M)[Mo2O2S4L] where (Et4N)2(1), L = S42 −, (Et4N)(2), L = Cp, (3), L = DMF, K(5), L = serine, M = Et4N+, K+, Na+ and [Mo2O2S2L2] where Na2(4), L = cysteine, and (6), L = threonine, were prepared and subjected to cytotoxicity studies in vitro. The results were analyzed to rank the compounds according to their relative cytotoxicity and to correlate the observed toxicity to specific composition. The results guide future efforts to synthesize highly water soluble, non-toxic, compounds. Strong correlation was observed between toxicity and cation selection, as well as selection of biocompatible ligands combined with alkali metal salts. The most toxic compound analyzed showed about 50 times less cytotoxicity than the cisplatin reference compound in HT-29 cells. Preliminary results from in vivo data agree with the ranking obtained in vitro.

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