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Retinal Oximetry with Scanning Laser Ophthalmoscope in Infants

Retinal Oximetry with Scanning Laser Ophthalmoscope in Infants

Title: Retinal Oximetry with Scanning Laser Ophthalmoscope in Infants
Author: Vehmeijer, Wouter B.
Magnusdottir, Vigdis
Eliasdottir, Thorunn   orcid.org/0000-0003-4217-7050
Hardarson, Sveinn Hakon   orcid.org/0000-0001-5865-6756
Schalij-Delfos, Nicoline E.
Stefánsson, Einar
Date: 2016-02-03
Language: English
Scope: e0148077
University/Institute: Háskóli Íslands
University of Iceland
School: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Department: Læknadeild (HÍ)
Faculty of Medicine (UI)
Series: Plos One;11(2)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0148077
Subject: Augnlækningar; Sjónhimna; Ungbörn
URI: https://hdl.handle.net/20.500.11815/1930

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Vehmeijer WB, Magnusdottir V, Eliasdottir TS, Hardarson SH, Schalij-Delfos NE, Stefánsson E (2016) Retinal Oximetry with Scanning Laser Ophthalmoscope in Infants. PLoS ONE 11(2): e0148077. https://doi.org/10.1371/journal.pone.0148077


Dual wavelength retinal oximetry has been developed for adults, but is not available for infants. Retinal oximetry may provide insight into the pathophysiology of oxygen-mediated diseases like retinopathy of prematurity. More insight in the oxygen metabolism of the retina in infants may provide valuable clues for better understanding and subsequent prevention or treatment of the disease. The measurements of oxygen saturation are obtained with two fundus images simultaneously captured in two different wavelengths of light. The comparison in light absorption of oxygenated and deoxygenated hemoglobin can be used to estimate the oxygen saturation within the retinal vessels by means of a software algorithm. This study aims to make retinal oximetry available for neonates. The first step towards estimating retinal oxygen saturation is determining the optical density ratio. Therefore, the purpose of this study is to image healthy newborn infants with a scanning laser ophthalmoscope and determine the optical density ratio for retinal oximetry analysis.


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2016 Vehmeijer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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