Retinal Oximetry with Scanning Laser Ophthalmoscope in Infants

Vehmeijer, Wouter B.; Magnusdottir, Vigdis; Eliasdottir, Thorunn; Hardarson, Sveinn Hakon; Schalij-Delfos, Nicoline E.; Stefánsson, Einar

Opin vísindi
→
Háskóli Íslands
→
Greinar- HÍ
→
Skoða verk

dc.contributor	Háskóli Íslands
dc.contributor	University of Iceland
dc.contributor.author	Vehmeijer, Wouter B.
dc.contributor.author	Magnusdottir, Vigdis
dc.contributor.author	orcid.org/0000-0003-4217-7050 Eliasdottir, Thorunn
dc.contributor.author	orcid.org/0000-0001-5865-6756 Hardarson, Sveinn Hakon
dc.contributor.author	Schalij-Delfos, Nicoline E.
dc.contributor.author	Stefánsson, Einar
dc.date.accessioned	2020-08-06T14:49:13Z
dc.date.available	2020-08-06T14:49:13Z
dc.date.issued	2016-02-03
dc.identifier.citation	Vehmeijer WB, Magnusdottir V, Eliasdottir TS, Hardarson SH, Schalij-Delfos NE, Stefánsson E (2016) Retinal Oximetry with Scanning Laser Ophthalmoscope in Infants. PLoS ONE 11(2): e0148077. https://doi.org/10.1371/journal.pone.0148077
dc.identifier.issn	1932-6203
dc.identifier.uri	https://hdl.handle.net/20.500.11815/1930
dc.description	Publisher's version (útgefin grein)
dc.description.abstract	Dual wavelength retinal oximetry has been developed for adults, but is not available for infants. Retinal oximetry may provide insight into the pathophysiology of oxygen-mediated diseases like retinopathy of prematurity. More insight in the oxygen metabolism of the retina in infants may provide valuable clues for better understanding and subsequent prevention or treatment of the disease. The measurements of oxygen saturation are obtained with two fundus images simultaneously captured in two different wavelengths of light. The comparison in light absorption of oxygenated and deoxygenated hemoglobin can be used to estimate the oxygen saturation within the retinal vessels by means of a software algorithm. This study aims to make retinal oximetry available for neonates. The first step towards estimating retinal oxygen saturation is determining the optical density ratio. Therefore, the purpose of this study is to image healthy newborn infants with a scanning laser ophthalmoscope and determine the optical density ratio for retinal oximetry analysis.
dc.description.sponsorship	This study was supported by the ODAS foundation (http://www.odasstichting.nl/) (Den Hoorn, The Netherlands) to NES; The Icelandic Center for Research (Rannís), Award nr.:141425-052, to ES; The University of Iceland Research Fund, to SHH; The Landspítali-University Hospital Research Fund, Award nr.: A-2015-011, to SHH; and the Helga Jónsdóttir and Sigurliði Kristjánsson Memorial Fund, to ES.
dc.format.extent	e0148077
dc.language.iso	en
dc.publisher	Public Library of Science (PLoS)
dc.relation.ispartofseries	Plos One;11(2)
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Augnlækningar
dc.subject	Sjónhimna
dc.subject	Ungbörn
dc.title	Retinal Oximetry with Scanning Laser Ophthalmoscope in Infants
dc.type	info:eu-repo/semantics/article
dcterms.license	2016 Vehmeijer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.description.version	Peer reviewed
dc.identifier.journal	Plos One
dc.identifier.doi	10.1371/journal.pone.0148077
dc.relation.url	http://dx.plos.org/10.1371/journal.pone.0148077
dc.contributor.department	Læknadeild (HÍ)
dc.contributor.department	Faculty of Medicine (UI)
dc.contributor.school	Heilbrigðisvísindasvið (HÍ)
dc.contributor.school	School of Health Sciences (UI)