Retinal Oximetry with Scanning Laser Ophthalmoscope in Infants

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dc.contributorHáskóli Íslandsen_US
dc.contributorUniversity of Icelanden_US
dc.contributor.authorVehmeijer, Wouter B.
dc.contributor.authorMagnusdottir, Vigdis
dc.contributor.authorEliasdottir, Thorunn
dc.contributor.authorHardarson, Sveinn Hakon
dc.contributor.authorSchalij-Delfos, Nicoline E.
dc.contributor.authorStefánsson, Einar
dc.contributor.departmentLæknadeild (HÍ)en_US
dc.contributor.departmentFaculty of Medicine (UI)en_US
dc.contributor.schoolHeilbrigðisvísindasvið (HÍ)en_US
dc.contributor.schoolSchool of Health Sciences (UI)en_US
dc.date.accessioned2020-08-06T14:49:13Z
dc.date.available2020-08-06T14:49:13Z
dc.date.issued2016-02-03
dc.descriptionPublisher's version (útgefin grein)en_US
dc.description.abstractDual wavelength retinal oximetry has been developed for adults, but is not available for infants. Retinal oximetry may provide insight into the pathophysiology of oxygen-mediated diseases like retinopathy of prematurity. More insight in the oxygen metabolism of the retina in infants may provide valuable clues for better understanding and subsequent prevention or treatment of the disease. The measurements of oxygen saturation are obtained with two fundus images simultaneously captured in two different wavelengths of light. The comparison in light absorption of oxygenated and deoxygenated hemoglobin can be used to estimate the oxygen saturation within the retinal vessels by means of a software algorithm. This study aims to make retinal oximetry available for neonates. The first step towards estimating retinal oxygen saturation is determining the optical density ratio. Therefore, the purpose of this study is to image healthy newborn infants with a scanning laser ophthalmoscope and determine the optical density ratio for retinal oximetry analysis.en_US
dc.description.sponsorshipThis study was supported by the ODAS foundation (http://www.odasstichting.nl/) (Den Hoorn, The Netherlands) to NES; The Icelandic Center for Research (Rannís), Award nr.:141425-052, to ES; The University of Iceland Research Fund, to SHH; The Landspítali-University Hospital Research Fund, Award nr.: A-2015-011, to SHH; and the Helga Jónsdóttir and Sigurliði Kristjánsson Memorial Fund, to ES.en_US
dc.description.versionPeer revieweden_US
dc.format.extente0148077en_US
dc.identifier.citationVehmeijer WB, Magnusdottir V, Eliasdottir TS, Hardarson SH, Schalij-Delfos NE, Stefánsson E (2016) Retinal Oximetry with Scanning Laser Ophthalmoscope in Infants. PLoS ONE 11(2): e0148077. https://doi.org/10.1371/journal.pone.0148077en_US
dc.identifier.doi10.1371/journal.pone.0148077
dc.identifier.issn1932-6203
dc.identifier.journalPlos Oneen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11815/1930
dc.language.isoenen_US
dc.publisherPublic Library of Science (PLoS)en_US
dc.relation.ispartofseriesPlos One;11(2)
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0148077en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAugnlækningaren_US
dc.subjectSjónhimnaen_US
dc.subjectUngbörnen_US
dc.titleRetinal Oximetry with Scanning Laser Ophthalmoscope in Infantsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dcterms.license2016 Vehmeijer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US

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