dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Thorisdottir, Birna |
dc.contributor.author |
Gunnarsdottir, Ingibjorg |
dc.contributor.author |
Viðarsdóttir, Anna Guðrún |
dc.contributor.author |
Sigurðardóttir, Sigurveig |
dc.contributor.author |
Birgisdottir, Bryndis Eva |
dc.contributor.author |
Thorsdottir, Inga |
dc.date.accessioned |
2020-03-31T11:48:42Z |
dc.date.available |
2020-03-31T11:48:42Z |
dc.date.issued |
2019-07-23 |
dc.identifier.citation |
Thorisdottir, B.; Gunnarsdottir, I.; Vidarsdottir, A.G.; Sigurdardottir, S.; Birgisdottir, B.E.; Thorsdottir, I. Infant Feeding, Vitamin D and IgE Sensitization to Food Allergens at 6 Years in a Longitudinal Icelandic Cohort. Nutrients 2019, 11, 1690. |
dc.identifier.issn |
2072-6643 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/1681 |
dc.description |
Publisher's version (útgefin grein) |
dc.description.abstract |
Nordic Nutrition Recommendations (NNR) recommend exclusive breastfeeding until 6 months, partial breastfeeding until 1 year or longer and irrespective of breastfeeding, avoiding solid foods before 4 months. Strong evidence was found for benefits of breastfeeding regarding growth and infections but limited/inconclusive evidence regarding atopic disease and asthma. Vitamin D is of special interest in the Nordic diet. The aim of this prospective study was to compare infant feeding and vitamin D between immunoglobulin E (IgE) sensitized (n = 14) and non-sensitized (n = 130) children at 6 years. Information on diet and vitamin D supplement use were collected with dietary recall (5 months), 1-d food records (5 and 6 months) and 3-d weighed food records (12 months and 6 years). Serum-specific IgE-antibodies against milk, egg, cod, wheat, soy and peanut (cut-off specific IgE ≥ 0.35 kUA/L) were measured at 6 years and serum 25-hydroxyvitamin D at 12 months and 6 years. At 4 months, 57% of IgE sensitized vs. 23% of non-sensitized children (p 0.01) had received solid food. At 12 months, IgE sensitized children had a lower intake of vitamin D (median (25th, 75th percentiles): 3.9 μg/d (3.2, 7.2) vs. 8.1 μg/d (4.4, 12.3), p = 0.03) and at 6 years, fewer used vitamin D supplements regularly (23% vs. 56%, p = 0.03). Introduction of solid foods prior to 4 months increased the odds of IgE-sensitization, OR = 4.9 (95%, CI = 1.4–16.6) and vitamin D supplement at 6 years decreased the odds of IgE-sensitization, OR = 0.2 (95%, CI = 0.1–0.98), adjusting for maternal smoking. These observations support the NNR in their recommendation against introducing complementary solid foods before the age of 4 months. Furthermore, they support encouraging vitamin D intake for young children at northern latitudes. |
dc.description.sponsorship |
This study was supported by the University of Iceland with a doctoral grant [HI15120056] and a grant from the University of Iceland Research Fund [2014–2016], Landspitali University Hospital [A-2016-034] and the Icelandic Centre for Research [050424031]. |
dc.format.extent |
1690 |
dc.language.iso |
en |
dc.publisher |
MDPI AG |
dc.relation.ispartofseries |
Nutrients;11(7) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Breastfeeding |
dc.subject |
Children |
dc.subject |
Complementary feeding |
dc.subject |
IgE sensitization |
dc.subject |
Infants |
dc.subject |
Nordic diet |
dc.subject |
Recommendations |
dc.subject |
Solid food |
dc.subject |
Vitamin D |
dc.subject |
Brjóstagjöf |
dc.subject |
Mataræði |
dc.subject |
Ungbörn |
dc.subject |
D vítamín |
dc.subject |
Tilviksrannsóknir |
dc.title |
Infant Feeding, Vitamin D and IgE Sensitization to Food Allergens at 6 Years in a Longitudinal Icelandic Cohort |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
Nutrients |
dc.identifier.doi |
10.3390/nu11071690 |
dc.relation.url |
https://www.mdpi.com/2072-6643/11/7/1690/pdf |
dc.contributor.department |
Matvæla- og næringarfræðideild (HÍ) |
dc.contributor.department |
Faculty of Food Science and Nutrition (UI) |
dc.contributor.department |
Félagsfræði-, mannfræði- og þjóðfræðideild (HÍ) |
dc.contributor.department |
Faculty of Sociology, Anthropology and Folkloristics (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |
dc.contributor.school |
Félagsvísindasvið (HÍ) |
dc.contributor.school |
School of Social Sciences (UI) |