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Infant Feeding, Vitamin D and IgE Sensitization to Food Allergens at 6 Years in a Longitudinal Icelandic Cohort

Infant Feeding, Vitamin D and IgE Sensitization to Food Allergens at 6 Years in a Longitudinal Icelandic Cohort


Title: Infant Feeding, Vitamin D and IgE Sensitization to Food Allergens at 6 Years in a Longitudinal Icelandic Cohort
Author: Thorisdottir, Birna   orcid.org/0000-0001-7320-0116
Gunnarsdottir, Ingibjorg   orcid.org/0000-0001-9447-8627
Viðarsdóttir, Anna Guðrún
Sigurðardóttir, Sigurveig
Birgisdottir, Bryndis Eva   orcid.org/0000-0002-5788-4551
Thorsdottir, Inga   orcid.org/0000-0002-2946-287X
Date: 2019-07-23
Language: English
Scope: 1690
University/Institute: Háskóli Íslands
University of Iceland
School: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Félagsvísindasvið (HÍ)
School of Social Sciences (UI)
Department: Matvæla- og næringarfræðideild (HÍ)
Faculty of Food Science and Nutrition (UI)
Félagsfræði-, mannfræði- og þjóðfræðideild (HÍ)
Faculty of Sociology, Anthropology and Folkloristics (UI)
Series: Nutrients;11(7)
ISSN: 2072-6643
DOI: 10.3390/nu11071690
Subject: Breastfeeding; Children; Complementary feeding; IgE sensitization; Infants; Nordic diet; Recommendations; Solid food; Vitamin D; Brjóstagjöf; Mataræði; Ungbörn; D vítamín; Tilviksrannsóknir
URI: https://hdl.handle.net/20.500.11815/1681

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Citation:

Thorisdottir, B.; Gunnarsdottir, I.; Vidarsdottir, A.G.; Sigurdardottir, S.; Birgisdottir, B.E.; Thorsdottir, I. Infant Feeding, Vitamin D and IgE Sensitization to Food Allergens at 6 Years in a Longitudinal Icelandic Cohort. Nutrients 2019, 11, 1690.

Abstract:

Nordic Nutrition Recommendations (NNR) recommend exclusive breastfeeding until 6 months, partial breastfeeding until 1 year or longer and irrespective of breastfeeding, avoiding solid foods before 4 months. Strong evidence was found for benefits of breastfeeding regarding growth and infections but limited/inconclusive evidence regarding atopic disease and asthma. Vitamin D is of special interest in the Nordic diet. The aim of this prospective study was to compare infant feeding and vitamin D between immunoglobulin E (IgE) sensitized (n = 14) and non-sensitized (n = 130) children at 6 years. Information on diet and vitamin D supplement use were collected with dietary recall (5 months), 1-d food records (5 and 6 months) and 3-d weighed food records (12 months and 6 years). Serum-specific IgE-antibodies against milk, egg, cod, wheat, soy and peanut (cut-off specific IgE ≥ 0.35 kUA/L) were measured at 6 years and serum 25-hydroxyvitamin D at 12 months and 6 years. At 4 months, 57% of IgE sensitized vs. 23% of non-sensitized children (p 0.01) had received solid food. At 12 months, IgE sensitized children had a lower intake of vitamin D (median (25th, 75th percentiles): 3.9 μg/d (3.2, 7.2) vs. 8.1 μg/d (4.4, 12.3), p = 0.03) and at 6 years, fewer used vitamin D supplements regularly (23% vs. 56%, p = 0.03). Introduction of solid foods prior to 4 months increased the odds of IgE-sensitization, OR = 4.9 (95%, CI = 1.4–16.6) and vitamin D supplement at 6 years decreased the odds of IgE-sensitization, OR = 0.2 (95%, CI = 0.1–0.98), adjusting for maternal smoking. These observations support the NNR in their recommendation against introducing complementary solid foods before the age of 4 months. Furthermore, they support encouraging vitamin D intake for young children at northern latitudes.

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