Title: | An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome—A SYSDIET Sub-Study |
Author: |
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Date: | 2019-12-03 |
Language: | English |
Scope: | 2932 |
University/Institute: | Háskóli Íslands University of Iceland |
School: | Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) |
Department: | Matvæla- og næringarfræðideild (HÍ) Faculty of Food Science and Nutrition (UI) |
Series: | Nutrients;11(12) |
ISSN: | 2072-6643 |
DOI: | 10.3390/nu11122932 |
Subject: | Metabolic syndrome; Randomized controlled dietary intervention; Gene expression; Peripheral blood mononuclear cells; Inflammation; Efnaskiptasjúkdómar; Bólgur; Mataræði; Genarannsóknir |
URI: | https://hdl.handle.net/20.500.11815/1516 |
Citation:Ulven, S.M. et al., 2019. An Isocaloric Nordic Diet Modulates and Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome-A SYSDIET Sub-Study. Nutrients, 11(12), pp.Nutrients, 03 December 2019, Vol.11(12).
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Abstract:A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and
reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet
(ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral
blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an
ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes
involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized
intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included
in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the
intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic
Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed.
The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A
(TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer
of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND
group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may
affect immune function.
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Description:Publisher's version (útgefin grein).
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Rights:This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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