IL-33 is a tissue-derived cytokine that induces and amplifies eosinophilic inflammation and has emerged as a promising new drug target for asthma and allergic disease. Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate with ...

Aims Scavenger receptor Class B Type 1 (SR-BI) is a major receptor for high-density lipoprotein (HDL) that promotes hepatic uptake of cholesterol from HDL. A rare mutation p.P376L, in the gene encoding SR-BI, SCARB1, was recently reported to associate ...

Migraine is a complex neurovascular disease with a range of severity and symptoms, yet mostly studied as one phenotype in genome-wide association studies (GWAS). Here we combine large GWAS datasets from six European populations to study the main migraine ...

Vaccines are the most effective medical intervention due to their continual success in preventing infections and improving mortality worldwide. Early vaccines were developed empirically however, rational design of vaccines can allow us to optimise their ...

This thesis studied the volcanic and geothermal source of arsenic (As) and its fate in shallow ground waters and upon entering the ocean by means of experimental and field measurements combined with geochemical modeling. Arsenic enters the atmosphere ...

The small-scale study presented here was the first test of three instruments in a sample of Icelandic children: IS-FORM, IS-PSEUDO, and the Strengths and Weaknesses of ADHD-symptoms and Normal-behavior (SWAN) rating scale. Participants in this study ...

Teachers who encounter difficulties when implementing technology in their classes often hesitate to give it another try. They expect too many technical problems to emerge, reducing time spent on learning mathematics. Still, if a task requires only ...

Objective: There is a lack of real-life studies on interleukin-17 (IL-17) inhibition in psoriatic arthritis (PsA). We assessed real-life 6- and 12-month effectiveness (i.e., retention, remission, low disease activity [LDA], and response rates) of the ...

Climate change mitigation in the built environment encompasses various mitigation measures, such as energy efficient buildings, spatial planning instruments and other policies targeting the emissions resulting from transport. However, studies on the ...

This article focuses upon issues that public policy makers need to address, when trying to stimulate world-leading research into new areas, which are potentially also valuable to solving societal challenges. Our analysis helps contribute to the theoretical ...