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Rational vaccine design in times of emerging diseases : The critical choices of immunological correlates of protection, vaccine antigen and immunomodulation

Rational vaccine design in times of emerging diseases : The critical choices of immunological correlates of protection, vaccine antigen and immunomodulation


Title: Rational vaccine design in times of emerging diseases : The critical choices of immunological correlates of protection, vaccine antigen and immunomodulation
Author: Schijns, Virgil
Majhen, Dragomira
Van Der Ley, Peter
Thakur, Aneesh
Summerfield, Artur
Berisio, Rita
Nativi, Cristina
Fernández-Tejada, Alberto
Álverez-Dominguez, Carmen
Gizurarson, Sveinbjörn
... 6 more authors Show all authors
Date: 2021-04-06
Language: English
Scope:
Department: Faculty of Pharmaceutical Sciences
Series: Pharmaceutics; 13(4)
ISSN: 1999-4923
DOI: https://doi.org/10.3390/pharmaceutics13040501
Subject: Bólusetningar; Bóluefni; Hönnun; Adjuvant; Antigen; Delivery system; Design; Immunization; Rational; Route; Vaccine; Pharmaceutical Science
URI: https://hdl.handle.net/20.500.11815/3138

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Citation:

Schijns , V , Majhen , D , Van Der Ley , P , Thakur , A , Summerfield , A , Berisio , R , Nativi , C , Fernández-Tejada , A , Álverez-Dominguez , C , Gizurarson , S , Zamyatina , A , Molinaro , A , Rosano , C , Jakopin , Ž , Gursel , I & McClean , S 2021 , ' Rational vaccine design in times of emerging diseases : The critical choices of immunological correlates of protection, vaccine antigen and immunomodulation ' , Pharmaceutics , vol. 13 , no. 4 , 501 . https://doi.org/10.3390/pharmaceutics13040501

Abstract:

Vaccines are the most effective medical intervention due to their continual success in preventing infections and improving mortality worldwide. Early vaccines were developed empirically however, rational design of vaccines can allow us to optimise their efficacy, by tailoring the immune response. Establishing the immune correlates of protection greatly informs the rational design of vaccines. This facilitates the selection of the best vaccine antigens and the most appropriate vaccine adjuvant to generate optimal memory immune T cell and B cell responses. This review outlines the range of vaccine types that are currently authorised and those under development. We outline the optimal immunological correlates of protection that can be targeted. Finally we review approaches to rational antigen selection and rational vaccine adjuvant design. Harnessing current knowledge on protective immune responses in combination with critical vaccine components is imperative to the prevention of future life-threatening diseases.

Description:

unding text Funding: This review was supported by Horizon 2020 EU COST Action CA16231 European Network of Vaccine Adjuvants. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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