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Browsing by Subject "Genetics"

Browsing by Subject "Genetics"

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  • Gudbjartsson, Daniel; Thorgeirsson, Gudmundur; sulem, patrick; Helgadottir, Anna; Gylfason, Arnaldur; Sæmundsdóttir, Jóna; Björnsson, Eyþór; Norðdahl, Guðmundur L.; Jónasdóttir, Áslaug; Jónasdóttir, Aðalbjörg; Eggertsson, Hannes; Grétarsdóttir, Sólveig; Thorleifsson, Gudmar; Indridason, Olafur Skuli; Palsson, Runolfur; Jónasson, Friðbert; Jonsdottir, Ingileif; Eyjólfsson, Guðmundur I.; Sigurðardóttir, Ólöf; Ólafsson, Ísleifur; Danielsen, Ragnar; Matthíasson, Stefán E.; Kristmundsdóttir, Snædís; Halldórsson, Bjarni V.; Hreiðarsson, Ástráður Benedikt; Valdimarsson, Einar M.; Gudnason, Thorarinn; Benediktsson, Rafn; Steinthorsdottir, Valgerdur; Thorsteinsdottir, Unnur; Holm, Hilma; Stefansson, Kari (Elsevier BV, 2019-12-17)
    Background: Lipoprotein(a) [Lp(a)] is a causal risk factor for cardiovascular diseases that has no established therapy. The attribute of Lp(a) that affects cardiovascular risk is not established. Low levels of Lp(a) have been associated with type 2 ...
  • Atacho, Diahann A. M.; Reynisson, Hallur; Pétursdóttir, Anna Þóra; Eysteinsson, Thor; Steingrimsson, Eirikur; Petersen, Petur Henry (Society for Neuroscience, 2020-03)
    Neuroplasticity forms the basis for neuronal circuit complexity and differences between otherwise similar circuits. We show that the microphthalmia-associated transcription factor (Mitf) plays a central role in intrinsic plasticity of olfactory bulb ...
  • Wesolowska, Natalia; Reynisdóttir, Sigrún; Ludwig, Michael Z.; Kreitman, Martin; Palsson, Arnar (Public Library of Science (PLoS), 2014-05-01)
    Changes in regulatory DNA contribute to phenotypic differences within and between taxa. Comparative studies show that many transcription factor binding sites (TFBS) are conserved between species whereas functional studies reveal that some mutations ...
  • Guðmundsson, Bjarki; Þormar, Hans G; Sigurðsson, Albert; Dankers, Wendy; Steinarsdóttir, Margrét; Hermanowicz, Stefan; Sigurðsson, Stefán; Ólafsson, Davið; Halldorsdottir, Anna; Meyn, Stephen; Jonsson, Jon J. (Oxford University Press (OUP), 2018-07-24)
    DNA damage assays have various limitations in types of lesions detected, sensitivity, specificity and samples that can be analyzed. The Northern Lights Assay (NLA) is based on 2D Strandness-Dependent Electrophoresis (2D-SDE), a technique that separates ...
  • Palsson, Arnar; Rouse, Ann; Riley-Berger, Rebecca; Dworkin, Ian; Gibson, Greg (Genetics Society of America, 2004-07-01)
    The Epidermal growth factor receptor is an essential gene with diverse pleiotropic roles in development throughout the animal kingdom. Analysis of sequence diversity in 10.9 kb covering the complete coding region and 6.4 kb of potential regulatory ...
  • Figueiredo Cardoso, Tainã; Amills, Marcel; Bertolini, Francesca; Rothschild, Max F.; Marras, Gabriele; Boink, Geert; Jordana, Jordi; Capote, Juan; Carolan, Sean; Hallsson, Jon; Kantanen, Juha; Pons, Àgueda L.; Lenstra, Johannes A. (Springer Nature America, Inc, 2018-11-19)
    Genetic isolation of breeds may result in a significant loss of diversity and have consequences on health and performance. In this study, we examined the effect of geographic isolation on caprine genetic diversity patterns by genotyping 480 individuals ...
  • Hess, Jonathan L.; Sigurdsson, Engilbert; Stefansson, Hreinn; Stefansson, Kari (Springer Science and Business Media LLC, 2019-09-06)
    Based on the discovery by the Resilience Project (Chen R. et al. Nat Biotechnol 34:531–538, 2016) of rare variants that confer resistance to Mendelian disease, and protective alleles for some complex diseases, we posited the existence of genetic variants ...
  • Björnsson, Þorsteinn; Þórólfsdóttir, Rósa B.; Sveinbjornsson, Gardar; sulem, patrick; Norðdahl, Guðmundur L.; Helgadóttir, Anna; Grétarsdóttir, Sólveig; Magnusdóttir, Auður; Danielsen, Ragnar; Sigurðsson, Emil Lárus; Adalsteinsdottir, Berglind; Gunnarsson, Sverrir I; Jonsdottir, Ingileif; Arnar, Davíð O.; Helgason, Hróðmar; Gudbjartsson, Tomas; Gudbjartsson, Daniel; Thorsteinsdottir, Unnur; Holm, Hilma; Stefansson, Kari (Oxford University Press (OUP), 2018-03-24)
    Aims Coarctation of the aorta (CoA) accounts for 4-8% of congenital heart defects (CHDs) and confers substantial morbidity despite treatment. It is increasingly recognized as a highly heritable condition. The aim of the study was to search for sequence ...
  • Silva, Ana I.; Ulfarsson, Magnus; Stefansson, Hreinn; Gústafsson, Ómar; Walters, G. Bragi; Linden, David E.J.; Wilkinson, Lawrence S.; Drakesmith, Mark; Owen, Michael J.; Hall, Jeremy; Stefansson, Kari (Elsevier BV, 2019-04-01)
    Background: The 15q11.2 BP1-BP2 cytogenetic region has been associated with learning and motor delays, autism, and schizophrenia. This region includes a gene that codes for the cytoplasmic FMR1 interacting protein 1 (CYFIP1). The CYFIP1 protein is ...
  • Juliusson, Haraldur Y.; Sigurdsson, Snorri (American Chemical Society (ACS), 2020-02-27)
    Electron paramagnetic resonance (EPR) spectroscopy, coupled with site-directed spin labeling (SDSL), is a useful method for studying conformational changes of biomolecules in cells. To employ in-cell EPR using nitroxide-based spin labels, the structure ...
  • Jinga, Viorel; Csiki, Irma Eva; Manolescu, Andrei; Iordache, Paul; Mates, Ioan Nicolae; Radavoi, Daniel; Rascu, Stefan; Badescu, Daniel; Badea, Paula; Mates, Dana (Wiley, 2016-01-15)
    Prostate cancer is the third‐most common form of cancer in men in Romania. The Romanian unscreened population represents a good sample to study common genetic risk variants. However, a comprehensive analysis has not been conducted yet. Here, we report ...
  • Benonisdottir, Stefania; Kristjansson, Ragnar P; Oddsson, Asmundur; Steinthorsdottir, Valgerdur; Mikaelsdottir, Evgenia; Kehr, Birte; Jensson, Brynjar O; Arnadottir, Gudny A; Sulem, Gerald; Sveinbjornsson, Gardar; Kristmundsdóttir, Snædís; Ívarsdóttir, Erna V.; Tragante, Vinicius; Gunnarsson, Bjarni; Runolfsdottir, Hrafnhildur Linnet; Arthur, Joseph G; Deaton, Aimee M; Eyjolfsson, Gudmundur I; Davidsson, Olafur B; Asselbergs, Folkert W; Hreidarsson, Astradur B; Rafnar, Thorunn; Thorleifsson, Gudmar; Edvardsson, Vidar; Sigurdsson, Gunnar; Helgadottir, Anna; Halldórsson, Bjarni; Masson, Gisli; Holm, Hilma; Önundarson, Páll Torfi; Indridason, Olafur S; Benediktsson, Rafn; Palsson, Runolfur; Gudbjartsson, Daniel F; Olafsson, Isleifur; Thorsteinsdottir, Unnur; sulem, patrick; Stefansson, Kari (Oxford University Press (OUP), 2018-11-24)
    Urine dipstick tests are widely used in routine medical care to diagnose kidney and urinary tract and metabolic diseases. Several environmental factors are known to affect the test results, whereas the effects of genetic diversity are largely unknown. ...
  • Wu, Peitao; Rybin, Denis; Bielak, Lawrence F.; Feitosa, Mary F.; Franceschini, Nora; Li, Yize; Lu, Yingchang; Marten, Jonathan; Musani, Solomon K.; Noordam, Raymond; Raghavan, Sridharan; Rose, Lynda M.; Schwander, Karen; Smith, Albert Vernon; Tajuddin, Salman M.; Vojinovic, Dina; Amin, Najaf; Arnett, Donna K.; Bottinger, Erwin P.; Demirkan, Ayse; Florez, Jose C.; Ghanbari, Mohsen; Harris, Tamara B.; Launer, Lenore J.; Liu, Jingmin; Liu, Jun; Mook-Kanamori, Dennis O.; Murray, Alison D.; Nalls, Mike A.; Peyser, Patricia A.; Uitterlinden, André G.; Voortman, Trudy; Bouchard, Claude; Chasman, Daniel; Correa, Adolfo; de Mutsert, Renée; Evans, Michele K.; Gudnason, Vilmundur; Hayward, Caroline; Kao, Linda; Kardia, Sharon L. R.; Kooperberg, Charles; Loos, Ruth J. F.; Province, Michael M.; Rankinen, Tuomo; Redline, Susan; Ridker, Paul M.; Rotter, Jerome I.; Siscovick, David; Smith, Blair H.; van Duijn, Cornelia; Zonderman, Alan B.; Rao, D. C.; Wilson, James G.; Dupuis, Josée; Meigs, James B.; Liu, Ching-Ti; Vassy, Jason L. (Public Library of Science (PLoS), 2020-05-07)
    Smoking is a potentially causal behavioral risk factor for type 2 diabetes (T2D), but not all smokers develop T2D. It is unknown whether genetic factors partially explain this variation. We performed genome-environment-wide interaction studies to ...
  • Wutke, Saskia; Benecke, Norbert; Sandoval-Castellanos, Edson; Döhle, Hans-Jürgen; Friederich, Susanne; Gonzalez, Javier; Hofreiter, Michael; Lõugas, Lembi; Magnell, Ola; Morales-Muniz, Arturo; Orlando, Ludovic; Reissmann, Monika; Ruttkay, Matej; Trinks, Alexandra; Ludwig, Arne; Palsdottir, Albina Hulda; Hallsson, Jon (Springer Nature, 2016-12-07)
    Horses have been valued for their diversity of coat colour since prehistoric times; this is especially the case since their domestication in the Caspian steppe in ~3,500 BC. Although we can assume that human preferences were not constant, we have only ...
  • Gustmann, Henrik; Segler, Anna-Lena J; Gophane, Dnyaneshwar B; Reuss, Andreas J; Grünewald, Christian; Braun, Markus; Weigand, Julia; Sigurdsson, Snorri; Wachtveitl, Josef (Oxford University Press (OUP), 2018-11-20)
    The ability of the cytidine analog Ç m f to act as a position specific reporter of RNA-dynamics was spectroscopically evaluated. Ç m f-labeled single-and double-stranded RNAs differ in their fluorescence lifetimes, quantum yields and anisotropies. These ...
  • Palsson, Arnar; Dodgson, James; Dworkin, Ian; Gibson, Greg (BioMed Central Ltd, 2005)
    Background Quantitative differences between individuals stem from a combination of genetic and environmental factors, with the heritable variation being shaped by evolutionary forces. Drosophila wing shape has emerged as an attractive system for ...
  • Skúlason, Skúli; Parsons, Kevin J.; Svanbäck, Richard; Räsänen, Katja; Ferguson, Moira M.; Adams, Colin E.; Amundsen, Per‐Arne; Bartels, Pia; Bean, Colin W.; Boughman, Janette W.; Englund, Göran; Guðbrandsson, Jóhannes; Hooker, Oliver E.; Hudson, Alan G.; Kahilainen, Kimmo K.; Knudsen, Rune; Kristjánsson, Bjarni K.; Leblanc, Camille; Jónsson, Zophonías Oddur; Öhlund, Gunnar; Smith, Carl; Snorrason, Sigurður S. (Wiley, 2019-06-19)
    A major goal of evolutionary science is to understand how biological diversity is generated and altered. Despite considerable advances, we still have limited insight into how phenotypic variation arises and is sorted by natural selection. Here we argue ...