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Replication study of 34 common SNPs associated with prostate cancer in the Romanian population

Replication study of 34 common SNPs associated with prostate cancer in the Romanian population


Titill: Replication study of 34 common SNPs associated with prostate cancer in the Romanian population
Höfundur: Jinga, Viorel
Csiki, Irma Eva
Manolescu, Andrei   orcid.org/0000-0002-0713-4664
Iordache, Paul   orcid.org/0000-0003-2248-8927
Mates, Ioan Nicolae
Radavoi, Daniel
Rascu, Stefan
Badescu, Daniel
Badea, Paula
Mates, Dana
Útgáfa: 2016-01-15
Tungumál: Enska
Umfang: 594-600
Háskóli/Stofnun: Háskólinn í Reykjavík
Reykjavik University
Deild: Tækni- og verkfræðideild (HR)
School of Science and Engineering (RU)
Birtist í: Journal of Cellular and Molecular Medicine;20(4)
ISSN: 1582-1838
1582-4934 (eISSN)
DOI: doi.org/10.1111/jcmm.12729
Efnisorð: Prostate cancer; Nucleotides; Genetics; Research; Blöðruhálskirtilskrabbamein; Kjarnsýrur; Erfðafræði; Rannsóknir
URI: https://hdl.handle.net/20.500.11815/876

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Tilvitnun:

Jinga, V., Csiki, I. E., Manolescu, A., Iordache, P., Mates, I. N., Radavoi, D., … Mates, D. (2016). Replication study of 34 common SNPs associated with prostate cancer in the Romanian population. Journal of Cellular and Molecular Medicine, 20(4), 594–600. doi.org/10.1111/jcmm.12729

Útdráttur:

Prostate cancer is the third‐most common form of cancer in men in Romania. The Romanian unscreened population represents a good sample to study common genetic risk variants. However, a comprehensive analysis has not been conducted yet. Here, we report our replication efforts in a Romanian population of 979 cases and 1027 controls, for potential association of 34 literature‐reported single nucleotide polymorphisms (SNPs) with prostate cancer. We also examined whether any SNP was differentially associated with tumour grade or stage at diagnosis, with disease aggressiveness, and with the levels of PSA (prostate specific antigen). In the allelic analysis, we replicated the previously reported risk for 19 loci on 4q24, 6q25.3, 7p15.2, 8q24.21, 10q11.23, 10q26.13, 11p15.5, 11q13.2, 11q13.3. Statistically significant associations were replicated for other six SNPs only with a particular disease phenotype: low‐grade tumour and low PSA levels (rs1512268), high PSA levels (rs401681 and rs11649743), less aggressive cancers (rs1465618, rs721048, rs17021918). The strongest association of our tested SNP's with PSA in controls was for rs2735839, with 29% increase for each copy of the major allele G, consistent with previous results. Our results suggest that rs4962416, previously associated only with prostate cancer, is also associated with PSA levels, with 12% increase for each copy of the minor allele C. The study enabled the replication of the effect for the majority of previously reported genetic variants in a set of clinically relevant prostate cancers. This is the first replication study on these loci, known to associate with prostate cancer, in a Romanian population.

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