Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti

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dc.contributor.authorDi, Xiaxia
dc.contributor.authorHarðardóttir, Ingibjörg
dc.contributor.authorFreysdóttir, Jóna
dc.contributor.authorWang, Dongdong
dc.contributor.authorGustafson, Kirk R
dc.contributor.authorÓmarsdóttir, Sesselja Sigurborg
dc.contributor.authorMolinski, Tadeusz F
dc.contributor.departmentFaculty of Medicine
dc.contributor.departmentFaculty of Pharmaceutical Sciences
dc.date.accessioned2025-11-20T09:13:22Z
dc.date.available2025-11-20T09:13:22Z
dc.date.issued2023-04
dc.descriptionFunding Information: This research was funded by University of Iceland Research Fund (Doctoral Grant and Project Grant), grant numbers not available, AVS R&D Fund of Ministry of Fisheries and Agriculture in Iceland, grant number R 029-14, the Landspitali University Hospital Research Fund (grant number not available), and the National Institutes of Health (AI100776, AT009783, to T.F.M.). Publisher Copyright: © 2023 by the authors.en
dc.description.abstractGeobarrettin D (1), a new bromoindole alkaloid, was isolated from the marine sponge Geodia barretti collected from Icelandic waters. Its structure was elucidated by 1D, and 2D NMR (including 1H-15N HSQC, 1H-15N HMBC spectra), as well as HRESIMS data. Geobarrettin D (1) is a new 6-bromoindole featuring an unusual purinium herbipoline moiety. Geobarrettin D (1) decreased secretion of the pro-inflammatory cytokine IL-12p40 by human monocyte derived dendritic cells, without affecting secretion of the anti-inflammatory cytokine IL-10. Thus, compound 1 shows anti-inflammatory activity.en
dc.description.versionPeer revieweden
dc.format.extent1045055
dc.format.extent
dc.identifier.citationDi, X, Harðardóttir, I, Freysdóttir, J, Wang, D, Gustafson, K R, Ómarsdóttir, S S & Molinski, T F 2023, 'Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti', Molecules, vol. 28, no. 7, 2937. https://doi.org/10.3390/molecules28072937en
dc.identifier.doi10.3390/molecules28072937
dc.identifier.issn1420-3049
dc.identifier.other122052833
dc.identifier.other9d36d9fc-e082-4514-a9e3-617c38a76941
dc.identifier.other37049700
dc.identifier.otherPubMedCentral: PMC10095911
dc.identifier.other85152332899
dc.identifier.otherunpaywall: 10.3390/molecules28072937
dc.identifier.urihttps://hdl.handle.net/20.500.11815/7166
dc.language.isoen
dc.relation.ispartofseriesMolecules; 28(7)en
dc.relation.urlhttps://www.scopus.com/pages/publications/85152332899en
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectGeodia/chemistryen
dc.subjectAlkaloids/pharmacologyen
dc.subjectCytokinesen
dc.subjectAnti-Inflammatory Agentsen
dc.subjectMolecular Structureen
dc.subjectdendritic cellsen
dc.subjectGeodia barrettien
dc.subjectherbipolineen
dc.subject6-bromoindoleen
dc.subjectanti-inflammatory activityen
dc.subjectDrug Discoveryen
dc.subjectAnalytical Chemistryen
dc.subjectChemistry (miscellaneous)en
dc.subjectMolecular Medicineen
dc.subjectPhysical and Theoretical Chemistryen
dc.subjectPharmaceutical Scienceen
dc.subjectOrganic Chemistryen
dc.titleGeobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barrettien
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/articleen

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