Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti
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Geobarrettin D (1), a new bromoindole alkaloid, was isolated from the marine sponge Geodia barretti collected from Icelandic waters. Its structure was elucidated by 1D, and 2D NMR (including 1H-15N HSQC, 1H-15N HMBC spectra), as well as HRESIMS data. Geobarrettin D (1) is a new 6-bromoindole featuring an unusual purinium herbipoline moiety. Geobarrettin D (1) decreased secretion of the pro-inflammatory cytokine IL-12p40 by human monocyte derived dendritic cells, without affecting secretion of the anti-inflammatory cytokine IL-10. Thus, compound 1 shows anti-inflammatory activity.
Lýsing
Funding Information: This research was funded by University of Iceland Research Fund (Doctoral Grant and Project Grant), grant numbers not available, AVS R&D Fund of Ministry of Fisheries and Agriculture in Iceland, grant number R 029-14, the Landspitali University Hospital Research Fund (grant number not available), and the National Institutes of Health (AI100776, AT009783, to T.F.M.). Publisher Copyright: © 2023 by the authors.
Efnisorð
Animals, Humans, Geodia/chemistry, Alkaloids/pharmacology, Cytokines, Anti-Inflammatory Agents, Molecular Structure, dendritic cells, Geodia barretti, herbipoline, 6-bromoindole, anti-inflammatory activity, Drug Discovery, Analytical Chemistry, Chemistry (miscellaneous), Molecular Medicine, Physical and Theoretical Chemistry, Pharmaceutical Science, Organic Chemistry
Citation
Di, X, Harðardóttir, I, Freysdóttir, J, Wang, D, Gustafson, K R, Ómarsdóttir, S S & Molinski, T F 2023, 'Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti', Molecules, vol. 28, no. 7, 2937. https://doi.org/10.3390/molecules28072937