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Fish oil in infancy protects against food allergy in Iceland-Results from a birth cohort study

Fish oil in infancy protects against food allergy in Iceland-Results from a birth cohort study


Titill: Fish oil in infancy protects against food allergy in Iceland-Results from a birth cohort study
Höfundur: Clausen, M.
Jónasson, Kristján   orcid.org/0000-0002-9066-3128
Keil, T.
Beyer, K.
Sigurdardottir, Sigurveig T   orcid.org/0000-0002-6275-0910
Útgáfa: 2018-01-31
Tungumál: Enska
Umfang: 1305-1312
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: School of Engineering and Natural Sciences (UI)
Verkfræði- og náttúruvísindasvið (HÍ)
Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Deild: Faculty of Medicine (UI)
Læknadeild (HÍ)
Birtist í: Allergy;73(6)
ISSN: 0105-4538
1398-9995 (eISSN)
DOI: 10.1111/all.13385
Efnisorð: Allergy prevention; EuroPrevall; Fish oil; Food allergy; Infants; Ofnæmi; Fæðuofnæmi; Meðganga; Lýsi; Ungbörn
URI: https://hdl.handle.net/20.500.11815/949

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Tilvitnun:

Clausen, M., Jonasson, K., Keil, T., Beyer, K., & Sigurdardottir, S. T. (2018). Fish oil in infancy protects against food allergy in Iceland—Results from a birth cohort study. Allergy, 73(6), 1305-1312. doi:doi:10.1111/all.13385

Útdráttur:

Background Consumption of oily fish or fish oil during pregnancy, lactation and infancy has been linked to a reduction in the development of allergic diseases in childhood. Methods In an observational study, Icelandic children (n = 1304) were prospectively followed from birth to 2.5 years with detailed questionnaires administered at birth and at 1 and 2 years of age, including questions about fish oil supplementation. Children with suspected food allergy were invited for physical examinations, allergic sensitization tests, and a double‐blind, placebo‐controlled food challenge if the allergy testing or clinical history indicated food allergy. The study investigated the development of sensitization to food and confirmed food allergy according to age and frequency of postnatal fish oil supplementation using proportional hazards modelling. Results The incidence of diagnosed food sensitization was significantly lower in children who received regular fish oil supplementation (relative risk: 0.51, 95% confidence interval: 0.32‐0.82). The incidence of challenge‐confirmed food allergy was also reduced, although not statistically significant (0.57, 0.30‐1.12). Children who began to receive fish oil in their first half year of life were significantly more protected than those who began later (P = .045 for sensitization, P = .018 for allergy). Indicators of allergy severity decreased with increased fish oil consumption (P = .013). Adjusting for parent education and allergic family history did not change the results. Conclusion Postnatal fish oil consumption is associated with decreased food sensitization and food allergies in infants and may provide an intervention strategy for allergy prevention.

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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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