Opin vísindi

Impact of parental cancer on IQ, stress resilience, and physical fitness in young men

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Chen, Ruoqing
dc.contributor.author Fall, Katja
dc.contributor.author Czene, Kamila
dc.contributor.author Kennedy, Beatrice
dc.contributor.author Valdimarsdottir, Unnur
dc.contributor.author Fang, Fang
dc.date.accessioned 2018-09-24T10:35:54Z
dc.date.available 2018-09-24T10:35:54Z
dc.date.issued 2018-05
dc.identifier.issn 1179-1349
dc.identifier.uri https://hdl.handle.net/20.500.11815/852
dc.description.abstract Background: A parental cancer diagnosis is a stressful life event, potentially leading to increased risks of mental and physical problems among children. This study aimed to investigate the associations of parental cancer with IQ, stress resilience, and physical fitness of the affected men during early adulthood. Materials and methods: In this Swedish population-based study, we included 465,249 men born during 1973–1983 who underwent the military conscription examination around the age of 18 years. We identified cancer diagnoses among the parents of these men from the Cancer Register. IQ, stress resilience, and physical fitness of the men were assessed at the time of conscription and categorized into three levels: low, moderate, and high (reference category). We used multinomial logistic regression to assess the studied associations. Results: Overall, parental cancer was associated with higher risks of low stress resilience (relative risk ratio [RRR]: 1.09 [95% confidence interval (CI) 1.04–1.15]) and low physical fitness (RRR: 1.12 [95% CI 1.05–1.19]). Stronger associations were observed for parental cancer with a poor expected prognosis (low stress resilience: RRR: 1.59 [95% CI 1.31–1.94]; low physical fitness: RRR: 1.45 [95% CI 1.14–1.85]) and for parental death after cancer diagnosis (low stress resilience: RRR: 1.29 [95% CI 1.16–1.43]; low physical fitness: RRR: 1.40 [95% CI 1.23–1.59]). Although there was no overall association between parental cancer and IQ, parental death after cancer diagnosis was associated with a higher risk of low IQ (RRR: 1.11 [95% CI 1.01–1.24]). Conclusion: Parental cancer, particularly severe and fatal type, is associated with higher risks of low stress resilience and low physical fitness among men during early adulthood. Men who experienced parental death after cancer diagnosis also have a higher risk of low IQ.
dc.description.sponsorship This study was supported by the Swedish Research Council for Health, Working Life and Welfare (grant number: 2012- 0498), and the Swedish Cancer Society (grant number: CAN 2014/417). Dr Fang was supported by the Karolinska Institutet (Senior Researcher Award and the Strategic Research Program in Epidemiology). Dr Chen was supported by the China Scholarship Council (no. 201206100002).
dc.format.extent 593-604
dc.language.iso en
dc.publisher Dove Medical Press Ltd.
dc.relation.ispartofseries Clinical Epidemiology;10
dc.rights info:eu-repo/semantics/openAccess
dc.subject Child of impaired parents
dc.subject Cancer
dc.subject Intelligence
dc.subject Resilience
dc.subject Physical fitness
dc.subject Krabbameinssjúklingar
dc.subject Krabbamein
dc.subject Börn
dc.subject Greind
dc.subject Seigla (persónuleikasálfræði)
dc.subject Heilsufar
dc.title Impact of parental cancer on IQ, stress resilience, and physical fitness in young men
dc.type info:eu-repo/semantics/article
dcterms.license This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
dc.description.version Peer Reviewed
dc.identifier.journal Clinical Epidemiology
dc.identifier.doi 10.2147/CLEP.S152210
dc.contributor.department Miðstöð í lýðheilsuvísindum (HÍ)
dc.contributor.department The Centre of Public Health Sciences (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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