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Browsing Doktorsritgerðir- HÍ by Subject "Brjóstakrabbamein"
Now showing items 1-13 of 13
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-11)Germline mutations in BRCA2 increase the risk of breast and ovarian cancer. The BRCA2 protein is involved in maintaining genomic stability through its roles in DNA double strand break repair and protection of stalled replication forks. The BRCA2 gene ... -
(University of Iceland, School of Health Sciences, Faculty of Medicine, 2020-12-02)Epithelial to mesenchymal transition (EMT) is a developmental trait that is hijacked in some disease conditions such as fibrosis and cancer. In cancer, EMT has been linked to increased invasion and metastasis, and is generally associated with a poor ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2022-05-24)Breast cancer is the leading cause of cancer deaths among women in Iceland and worldwide. Epithelial-mesenchymal transition (EMT) is a cellular developmental process where epithelial cells assume mesenchymal-like phenotypes through degradation of the ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-09)The overall aim of this PhD thesis was to cohesively assess the availability and use of electronic genealogy databases and information from cancer registries to construct electronically generated pedigrees for risk assessment in genetic counselling. ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-05)The DNA damage response is crucial to maintaining the integrity of DNA and the health of a cell. Unrepaired lesions within the DNA can lead to genomic instability and potentially aid in the formation of diseases such as cancer. Some cancers possess ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2018)Brjóstkirtillinn er myndaður af greinóttum kirtilgöngum sem umluktir eru æðaþelsríkum bandvef. Brjóstakrabbamein á upptök í kirtilþekjufrumum í endum kirtilganga. Brjóstakrabbameinsfrumur nýta sér ferli sem kallast bandvefsumbreyting þekjuvefjar til ...
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(2021-04)A better understanding of normal organ development can give deeper insight into which genes are harnessed by aberrant cells during cancer formation and progression. In my thesis, I have investigated two seemingly different, however, related, developmental ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2016-12)Background and aims: Previous studies in geothermal and volcanic areas have shown high risk of certain types of cancers. The aim was to study the association between residence in geothermal areas and the incidence and mortality of cancer in ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-08)The microenvironment is increasingly being recognized as a key player in supporting cancer progression. Therefore, investigating heterotypic interactions between cancer cells and their microenvironment is important for improving our understanding ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2021-06-15)Breast cancer is the most common type of cancer in women worldwide. It is also a highly heterogeneous disease that is characterized by an array of genetic rearrangements, including copy number alterations (CNA), translocations, inversions, ...
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Metabolic systems analysis of breast epithelial cells following epithelial-to-mesenchymal transition (University of Iceland, School of Health Sciences, Faculty of Medicine, 2022-02-25)Breast cancer is a heterogenous disease in which the mechanism for signalling, gene expression, metabolism and growth in breast tissue is deranged. Breast cancer is responsible for the death of over 600,000 people worldwide on a yearly basis. By ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2023-03-30)Breast cancer is the most frequently diagnosed cancer today, with approximately 2.3 million new cases for the year 2020. Regardless of gender, these diagnoses represent 11.7% of all cases. For women, breast cancer falls under roughly one-third of cancer ...
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(University of Iceland, School of Health Sciences, Faculty of Food Science and Nutrition, 2020-02)Background and aims : Previous studies have provided evidence for the importance of early life environment on breast cancer development. The aim of this study was to advance knowledge on the association of growth rate in early life and lifelong ...
Now showing items 1-13 of 13