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Outcome and survival of myeloma patients diagnosed 2008–2015. Real-world data on 4904 patients from the Swedish Myeloma Registry

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Blimark, Cecilie Hveding
dc.contributor.author Turesson, Ingemar
dc.contributor.author Genell, Anna
dc.contributor.author Ahlberg, Lucia
dc.contributor.author Björkstrand, Bo
dc.contributor.author Carlson, Kristina
dc.contributor.author Forsberg, Karin
dc.contributor.author Juliusson, Gunnar
dc.contributor.author Linder, Olle
dc.contributor.author Mellqvist, Ulf-Henrik
dc.contributor.author Nahi, Hareth
dc.contributor.author Kristinsson, Sigurður Yngvi
dc.date.accessioned 2018-07-26T11:31:35Z
dc.date.available 2018-07-26T11:31:35Z
dc.date.issued 2017-12-07
dc.identifier.citation Blimark, C. H., Turesson, I., Genell, A., Ahlberg, L., Björkstrand, B., Carlson, K., . . . Kristinsson, S. Y. (2018). Outcome and survival of myeloma patients diagnosed 2008–2015. Real-world data on 4904 patients from the Swedish Myeloma Registry. Haematologica, 103(3), 506-513. doi:10.3324/haematol.2017.178103
dc.identifier.issn 0390-6078
dc.identifier.issn 1592-8721 (eISSN)
dc.identifier.uri https://hdl.handle.net/20.500.11815/747
dc.description Epub ahead of print
dc.description.abstract Epidemiology and outcome of myeloma are mainly reported from large university centers and collaborative groups, and do not represent ‘real-world’ patients. The Swedish Myeloma Registry is a prospective population-based registry documenting characteristics, treatment and outcome in newly diagnosed myeloma, including asymptomatic and localized forms, with the purpose of improving disease management and outcome. This report presents information on patients diagnosed between 2008 and 2015, including data on first-line treatment in patients diagnosed up to 2014, with a follow up until December 2016. We present age-adjusted incidence, patients’ characteristics at baseline, treatment, response, and survival. Baseline data were available with a 97% coverage in 4904 patients (median age 71 years, males 70 years, females 73 years; 72% were 65 years or older), and at 1-year follow up in 3558 patients with symptomatic disease (92% of patients initially reported). The age-adjusted incidence was 6.8 myeloma cases per 100,000 inhabitants per year. Among initially symptomatic patients (n=3988), 77% had osteolytic lesions or compression fractures, 49% had anemia, 18% impaired kidney function, and 13% hypercalcemia. High-dose therapy with autologous stem cell transplantation was given to 77% of patients aged up to 66 years, and to 22% of patients aged 66–70 years. In the study period, 68% received bortezomib, thalidomide, and/or lenalidomide as part of the first-line treatment, rising from 31% in 2008 to 81% in 2014. In active myeloma, the median relative survival of patients aged 65 years or under was 7.7 years, and 3.4 years in patients aged 66 years and over. Patients diagnosed with myeloma in more recent years were associated with significantly higher rates of complete or very good partial remission (P<0.05), and with a significantly higher survival, with a Hazard Ratio (HR) of 0.84 (95%CI: 0.77–0.92; P<0.05). There was a small, but significant survival benefit in patients treated at university hospitals (HR 0.93; 95%CI: 0.87–0.99; P<0.05). We report here on a near complete ‘real-world’ population of myeloma patients during an 8-year period; a period in which newer drugs were implemented into standard practice. The overall incidence and median age were both higher than in most previous studies, indicating a more complete coverage of older patients. Myeloma survival in Sweden is comparable to other large registry studies, and responses and survival improved during the study period.
dc.format.extent 506-513
dc.language.iso en
dc.publisher Ferrata Storti Foundation (Haematologica)
dc.relation.ispartofseries Haematologica;103(3)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Faraldsfræði
dc.subject Mergæxli
dc.subject Sjúkdómsgreiningar
dc.subject Meðferð
dc.title Outcome and survival of myeloma patients diagnosed 2008–2015. Real-world data on 4904 patients from the Swedish Myeloma Registry
dc.type info:eu-repo/semantics/article
dc.description.version Peer Reviewed
dc.identifier.journal Haematologica
dc.identifier.doi 10.3324/haematol.2017.178103
dc.relation.url https://syndication.highwire.org/content/doi/10.3324/haematol.2017.178103
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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