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Profile of common prostate cancer risk variants in an unscreened Romanian population

Profile of common prostate cancer risk variants in an unscreened Romanian population


Titill: Profile of common prostate cancer risk variants in an unscreened Romanian population
Höfundur: Iordache, Paul   orcid.org/0000-0003-2248-8927
Mates, Dana
Gunnarsson, Bjarni
Eggertsson, Hannes P.
Sulem, Patrick   orcid.org/0000-0001-7123-6123
Guðmundsson, Júlíus
Benónísdóttir, Stefanía
Csiki, Irma Eva
Rascu, Stefan
Radavoi, Daniel
... 16 fleiri höfundar Sýna alla höfunda
Útgáfa: 2017-12-20
Tungumál: Enska
Umfang: 1574-1582
Háskóli/Stofnun: Háskólinn í Reykjavík
Reykjavik University
Háskóli Íslands
University of Iceland
Svið: Tækni- og verkfræðideild (HR)
School of Science and Engineering (RU)
Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Deild: Læknadeild (HÍ)
Faculty of Medicine (UI)
Birtist í: Journal of Cellular and Molecular Medicine;22(3)
ISSN: 1582-1838
1582-4934 (eISSN)
DOI: 10.1111/jcmm.13433
Efnisorð: Prostate cancer; GWAS; Romania; Genome‐wide association study; Unscreened population; Blöðruhálskirtilskrabbamein; Erfðagreining; Erfðafræði; Rannsóknir
URI: https://hdl.handle.net/20.500.11815/739

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Tilvitnun:

D., I. P., Dana, M., Bjarni, G., P., E. H., Patrick, S., Júlíus, G., . . . Kári, S. (2018). Profile of common prostate cancer risk variants in an unscreened Romanian population. Journal of Cellular and Molecular Medicine, 22(3), 1574-1582. doi:doi:10.1111/jcmm.13433

Útdráttur:

To find sequence variants affecting prostate cancer (PCA) susceptibility in an unscreened Romanian population we use a genome‐wide association study (GWAS). The study population included 990 unrelated pathologically confirmed PCA cases and 1034 male controls. DNA was genotyped using Illumina SNP arrays, and 24.295.558 variants were imputed using the 1000 Genomes data set. An association test was performed between the imputed markers and PCA. A systematic literature review for variants associated with PCA risk identified 115 unique variants that were tested in the Romanian sample set. Thirty of the previously reported SNPs replicated (P‐value < 0.05), with the strongest associations observed at: 8q24.21, 11q13.3, 6q25.3, 5p15.33, 22q13.2, 17q12 and 3q13.2. The replicated variants showing the most significant association in Romania are rs1016343 at 8q24.21 (P = 2.2 × 10−4), rs7929962 at 11q13.3 (P = 2.7 × 10−4) and rs9364554 at 6q25.2 (P = 4.7 × 10−4). None of the variants tested in the Romanian GWAS reached genome‐wide significance (P‐value <5 × 10−8) but 807 markers had P‐values <1 × 10−4. Here, we report the results of the first GWAS of PCA performed in a Romanian population. Our study provides evidence that a substantial fraction of previously validated PCA variants associate with risk in this unscreened Romanian population.

Leyfi:

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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