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Association Between Nucleotide Variation in Egfr and Wing Shape in Drosophila melanogaster

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Palsson, Arnar
dc.contributor.author Gibson, Greg
dc.date.accessioned 2018-02-28T15:37:18Z
dc.date.available 2018-02-28T15:37:18Z
dc.date.issued 2004-07-01
dc.identifier.citation Arnar Palsson and Greg Gibson Genetics July 1, 2004 vol. 167 no. 3 1187-1198; doi:10.1534/genetics.103.021766
dc.identifier.issn 0016-6731
dc.identifier.issn 1943-2631 (eISSN)
dc.identifier.uri https://hdl.handle.net/20.500.11815/585
dc.description.abstract As part of an effort to dissect quantitative trait locus effects to the nucleotide level, association was assessed between 238 single-nucleotide and 20 indel polymorphisms spread over 11 kb of the Drosophila melanogaster Egfr locus and nine relative warp measures of wing shape. One SNP in a conserved potential regulatory site for a GAGA factor in the promoter of alternate first exon 2 approaches conservative experiment-wise significance (P < 0.00003) in the sample of 207 lines for association with the location of the crossveins in the central region of the wing. Several other sites indicate marginal association with one or more other aspects of shape. No strong effects of sex or population of origin were detected with measures of shape, but two different sites were strongly associated with overall wing size in interaction with these fixed factors. Whole-gene sequencing in very large samples, rather than selective genotyping, would appear to be the only strategy likely to be successful for detecting subtle associations in species with high polymorphism and little haplotype structure. However, these features severely limit the ability of linkage disequilibrium mapping in Drosophila to resolve quantitative effects to single nucleotides.
dc.description.sponsorship A.P. was funded in part by awards from the American Scandinavian Foundation and NATO, and the project was funded by grants to G.G. from the David and Lucille Packard Foundation and the National Institutes of Health (R01 GM61600).
dc.format.extent 1187-1198
dc.language.iso en
dc.publisher Genetics Society of America
dc.relation.ispartofseries Genetics;167(3)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Genetics
dc.subject Quantitative genetics
dc.subject Erfðafræði
dc.title Association Between Nucleotide Variation in Egfr and Wing Shape in Drosophila melanogaster
dc.type info:eu-repo/semantics/article
dc.description.version Peer Reviewed
dc.identifier.journal Genetics
dc.identifier.doi 10.1534/genetics.103.021766
dc.relation.url https://syndication.highwire.org/content/doi/10.1534/genetics.103.021766
dc.contributor.department Líf- og umhverfisvísindadeild (HÍ)
dc.contributor.department Faculty of Life and Environmental Sciences (UI)
dc.contributor.school Verkfræði- og náttúruvísindasvið (HÍ)
dc.contributor.school School of Engineering and Natural Sciences (UI)

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