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Fletta eftir höfundi "Gudmundsson, Gudmundur H"

Fletta eftir höfundi "Gudmundsson, Gudmundur H"

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    Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia 
    Arason, Ari Jon; Jóelsson, Jón Pétur; Valdimarsdóttir, Bryndís; Sigurdsson, Snaevar; Guðjónsson, Alexander; Halldorsson, Skarphedinn; Jóhannsson, Freyr; Rolfsson, Óttar; Lehmann, Fredrik; Ingthorsson, Saevar; Cherek, Paulina; Gudmundsson, Gudmundur H; Garðarsson, Friðrik R.; Page, Clive P.; Baldursson, Ólafur; Gudjonsson, Thorarinn; Kricker, Jennifer (Springer Science and Business Media LLC, 2019-06-24)
    BACKGROUND: Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its anti-microbial activity or other ...
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    Bordetella pertussis Adenylate Cyclase Toxin Disrupts Functional Integrity of Bronchial Epithelial Layers 
    Hasan, Shakir; Kulkarni, Nikhil Nitin; Asbjarnarson, Arni; Linhartova, Irena; Osicka, Radim; Sebo, Peter; Gudmundsson, Gudmundur H (American Society for Microbiology, 2017-12-04)
    The airway epithelium restricts the penetration of inhaled pathogens into the underlying tissue and plays a crucial role in the innate immune defense against respiratory infections. The whooping cough agent, Bordetella pertussis, adheres to ciliated ...
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    Host Directed Therapy Against Infection by Boosting Innate Immunity 
    Bergman, Peter; Raqib, Rubhana; Rekha, Rokeya Sultana; Agerberth, Birgitta; Gudmundsson, Gudmundur H (Frontiers Media SA, 2020-06-12)
    The innate immune system constitutes the first line of defense against invading pathogens, regulating the normal microbiota and contributes to homeostasis. Today we have obtained detailed knowledge on receptors, signaling pathways, and effector molecules ...
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    Novel aroylated phenylenediamine compounds enhance antimicrobial defense and maintain airway epithelial barrier integrity 
    Myszor, Iwona Teresa; Parveen, Zahida; Ottosson, Håkan; Bergman, Peter; Agerberth, Birgitta; Strömberg, Roger; Gudmundsson, Gudmundur H (Springer Science and Business Media LLC, 2019-05-08)
    Aroylated phenylenediamines (APDs) are novel inducers of innate immunity enhancing cathelicidin gene expression in human bronchial epithelial cell lines. Here we present two newly developed APDs and aimed at defining the response and signaling pathways ...