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Topical Formulation Comprising Fatty Acid Extract from Cod Liver Oil: Development, Evaluation and Stability Studies

Topical Formulation Comprising Fatty Acid Extract from Cod Liver Oil: Development, Evaluation and Stability Studies


Titill: Topical Formulation Comprising Fatty Acid Extract from Cod Liver Oil: Development, Evaluation and Stability Studies
Höfundur: Ilievska, Biljana
Loftsson, Thorsteinn   orcid.org/0000-0002-9439-1553
Hjálmarsdóttir, Martha Ásdís   orcid.org/0000-0002-9764-9943
Ásgrimsdóttir, Guðrún
Útgáfa: 2016-06-01
Tungumál: Enska
Umfang: 105
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Deild: Lyfjafræðideild (HÍ)
Faculty of Pharmaceutical Sciences (UI)
Læknadeild (HÍ)
Faculty of Medicine (UI)
Birtist í: Marine Drugs;14(6)
ISSN: 1660-3397
DOI: 10.3390/md14060105
Efnisorð: Polyunsaturated fatty acid; Docosahexaenoic acid; Cosapentaenoic acid; Fatty acid; Ointment; Fitusýrur; Fjölómettaðar fitusýrur
URI: https://hdl.handle.net/20.500.11815/408

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Tilvitnun:

Ilievska, B.; Loftsson, T.; Hjalmarsdottir, M.A.; Asgrimsdottir, G.M. Topical Formulation Comprising Fatty Acid Extract from Cod Liver Oil: Development, Evaluation and Stability Studies. Mar. Drugs 2016, 14, 105. doi:10.3390/md14060105

Útdráttur:

The purpose of this study was to develop a pharmaceutical formulation containing fatty acid extract rich in free omega-3 fatty acids such as eicosapentaenoic acid and docosahexaenoic acid for topical use. Although the health benefits of cod liver oil and other fish oils taken orally as a dietary supplement have been acknowledged and exploited, it is clear that their use can be extended further to cover their antibacterial properties. In vitro evaluation showed that 20% (v/v) fatty acid extract exhibits good activity against strains of the Gram-positive bacteria Staphylococcus aureus, Enterococcus faecalis, Streptoccoccus pyogenes and Streptoccoccus pneumonia. Therefore, free polyunsaturated fatty acids from cod liver oil or other fish oils can be used as safe and natural antibacterial agents. In this study, ointment compositions containing free fatty acids as active antibacterial agents were prepared by using various natural waxes and characterized. The effects of different waxes, such as carnauba wax, ozokerite wax, laurel wax, beeswax, rice bran wax, candelilla wax and microcrystalline wax, in the concentration range of 1% to 5% (w/w) on the ointment texture, consistency and stability were evaluated. The results showed significant variations in texture, sensory and rheological profiles. This was attributed to the wax’s nature and chain composition. Microcrystalline wax gave the best results but laurel wax, beeswax and rice bran wax exhibited excellent texturing, similar sensory profiles and well-balanced rheological properties.

Leyfi:

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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