Topical Formulation Comprising Fatty Acid Extract from Cod Liver Oil: Development, Evaluation and Stability Studies

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dc.contributorHáskóli Íslandsen_US
dc.contributorUniversity of Icelanden_US
dc.contributor.authorIlievska, Biljana
dc.contributor.authorLoftsson, Thorsteinn
dc.contributor.authorHjálmarsdóttir, Martha Ásdís
dc.contributor.authorÁsgrimsdóttir, Guðrún
dc.contributor.departmentLyfjafræðideild (HÍ)en_US
dc.contributor.departmentFaculty of Pharmaceutical Sciences (UI)en_US
dc.contributor.departmentLæknadeild (HÍ)en_US
dc.contributor.departmentFaculty of Medicine (UI)en_US
dc.contributor.schoolHeilbrigðisvísindasvið (HÍ)en_US
dc.contributor.schoolSchool of Health Sciences (UI)en_US
dc.date.accessioned2017-09-25T14:16:46Z
dc.date.available2017-09-25T14:16:46Z
dc.date.issued2016-06-01
dc.description.abstractThe purpose of this study was to develop a pharmaceutical formulation containing fatty acid extract rich in free omega-3 fatty acids such as eicosapentaenoic acid and docosahexaenoic acid for topical use. Although the health benefits of cod liver oil and other fish oils taken orally as a dietary supplement have been acknowledged and exploited, it is clear that their use can be extended further to cover their antibacterial properties. In vitro evaluation showed that 20% (v/v) fatty acid extract exhibits good activity against strains of the Gram-positive bacteria Staphylococcus aureus, Enterococcus faecalis, Streptoccoccus pyogenes and Streptoccoccus pneumonia. Therefore, free polyunsaturated fatty acids from cod liver oil or other fish oils can be used as safe and natural antibacterial agents. In this study, ointment compositions containing free fatty acids as active antibacterial agents were prepared by using various natural waxes and characterized. The effects of different waxes, such as carnauba wax, ozokerite wax, laurel wax, beeswax, rice bran wax, candelilla wax and microcrystalline wax, in the concentration range of 1% to 5% (w/w) on the ointment texture, consistency and stability were evaluated. The results showed significant variations in texture, sensory and rheological profiles. This was attributed to the wax’s nature and chain composition. Microcrystalline wax gave the best results but laurel wax, beeswax and rice bran wax exhibited excellent texturing, similar sensory profiles and well-balanced rheological properties.en_US
dc.description.versionPeer Revieweden_US
dc.format.extent105en_US
dc.identifier.citationIlievska, B.; Loftsson, T.; Hjalmarsdottir, M.A.; Asgrimsdottir, G.M. Topical Formulation Comprising Fatty Acid Extract from Cod Liver Oil: Development, Evaluation and Stability Studies. Mar. Drugs 2016, 14, 105. doi:10.3390/md14060105en_US
dc.identifier.doi10.3390/md14060105
dc.identifier.issn1660-3397
dc.identifier.journalMarine Drugsen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11815/408
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofseriesMarine Drugs;14(6)
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolyunsaturated fatty aciden_US
dc.subjectDocosahexaenoic aciden_US
dc.subjectCosapentaenoic aciden_US
dc.subjectFatty aciden_US
dc.subjectOintmenten_US
dc.subjectFitusýruren_US
dc.subjectFjölómettaðar fitusýruren_US
dc.titleTopical Formulation Comprising Fatty Acid Extract from Cod Liver Oil: Development, Evaluation and Stability Studiesen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dcterms.licenseThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).en_US

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