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Associations of Pulmonary Function with MRI Brain Volumes : A Coordinated Multi-Study Analysis

Associations of Pulmonary Function with MRI Brain Volumes : A Coordinated Multi-Study Analysis


Titill: Associations of Pulmonary Function with MRI Brain Volumes : A Coordinated Multi-Study Analysis
Höfundur: Frenzel, Stefan
Bis, Joshua C.
Gudmundsson, Elias F.
O'Donnell, Adrienne
Simino, Jeannette
Yaqub, Amber
Bartz, Traci M.
Brusselle, Guy G.O.
Bülow, Robin
DeCarli, Charles S.
... 30 fleiri höfundar Sýna alla höfunda
Útgáfa: 2022-11-22
Tungumál: Enska
Umfang: 11
Deild: Faculty of Medicine
Birtist í: Journal of Alzheimer's disease : JAD; 90(3)
ISSN: 1387-2877
DOI: https://doi.org/10.3233/JAD-220667
Efnisorð: Dementia; epidemiology; magnetic resonance imaging; respiratory function tests; Neuroscience (all); Clinical Psychology; Geriatrics and Gerontology; Psychiatry and Mental Health
URI: https://hdl.handle.net/20.500.11815/3895

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Tilvitnun:

Frenzel , S , Bis , J C , Gudmundsson , E F , O'Donnell , A , Simino , J , Yaqub , A , Bartz , T M , Brusselle , G G O , Bülow , R , DeCarli , C S , Ewert , R , Gharib , S A , Ghosh , S , Gireud-Goss , M , Gottesman , R F , Ikram , M A , Knopman , D S , Launer , L J , London , S J , Longstreth , W T , Lopez , O L , Melo van Lent , D , O'Connor , G , Satizabal , C L , Shrestha , S , Sigurdsson , S , Stubbe , B , Talluri , R , Vasan , R S , Vernooij , M W , Völzke , H , Wiggins , K L , Yu , B , Beiser , A S , Gudnason , V , Mosley , T , Psaty , B M , Wolters , F J , Grabe , H J & Seshadri , S 2022 , ' Associations of Pulmonary Function with MRI Brain Volumes : A Coordinated Multi-Study Analysis ' , Journal of Alzheimer's disease : JAD , vol. 90 , no. 3 , pp. 1073-1083 . https://doi.org/10.3233/JAD-220667

Útdráttur:

BACKGROUND: Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent. OBJECTIVE: To study the cross-sectional associations of pulmonary function with structural brain variables. METHODS: Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities were investigated using multivariable linear regressions for each study separately and then combined using random-effect meta-analyses. RESULTS: FEV1 and FVC were positively associated with brain volume, gray matter volume, and hippocampal volume, and negatively associated with white matter hyperintensities volume after multiple testing correction, with little heterogeneity present between the studies. For instance, an increase of FVC by one unit was associated with 3.5 ml higher brain volume (95% CI: [2.2, 4.9]). In contrast, results for FEV1/FVC were more heterogeneous across studies, with significant positive associations with brain volume, gray matter volume, and hippocampal volume, but not white matter hyperintensities volume. Associations of brain variables with both FEV1 and FVC were consistently stronger than with FEV1/FVC, specifically with brain volume and white matter hyperintensities volume. CONCLUSION: In cross-sectional analyses, worse pulmonary function is associated with smaller brain volumes and higher white matter hyperintensities burden.

Athugasemdir:

This study was supported by National Institute of Health (NIH) grant AG059421. Additional study-specific acknowledgements can be found in the Supplementary Material.

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