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Associations of Pulmonary Function with MRI Brain Volumes : A Coordinated Multi-Study Analysis

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dc.contributor.author Frenzel, Stefan
dc.contributor.author Bis, Joshua C.
dc.contributor.author Gudmundsson, Elias F.
dc.contributor.author O'Donnell, Adrienne
dc.contributor.author Simino, Jeannette
dc.contributor.author Yaqub, Amber
dc.contributor.author Bartz, Traci M.
dc.contributor.author Brusselle, Guy G.O.
dc.contributor.author Bülow, Robin
dc.contributor.author DeCarli, Charles S.
dc.contributor.author Ewert, Ralf
dc.contributor.author Gharib, Sina A.
dc.contributor.author Ghosh, Saptaparni
dc.contributor.author Gireud-Goss, Monica
dc.contributor.author Gottesman, Rebecca F.
dc.contributor.author Ikram, M. Arfan
dc.contributor.author Knopman, David S.
dc.contributor.author Launer, Lenore J.
dc.contributor.author London, Stephanie J.
dc.contributor.author Longstreth, W. T.
dc.contributor.author Lopez, Oscar L.
dc.contributor.author Melo van Lent, Debora
dc.contributor.author O'Connor, George
dc.contributor.author Satizabal, Claudia L.
dc.contributor.author Shrestha, Srishti
dc.contributor.author Sigurdsson, Sigurdur
dc.contributor.author Stubbe, Beate
dc.contributor.author Talluri, Rajesh
dc.contributor.author Vasan, Ramachandran S.
dc.contributor.author Vernooij, Meike W.
dc.contributor.author Völzke, Henry
dc.contributor.author Wiggins, Kerri L.
dc.contributor.author Yu, Bing
dc.contributor.author Beiser, Alexa S.
dc.contributor.author Gudnason, Vilmundur
dc.contributor.author Mosley, Thomas
dc.contributor.author Psaty, Bruce M.
dc.contributor.author Wolters, Frank J.
dc.contributor.author Grabe, Hans J.
dc.contributor.author Seshadri, Sudha
dc.date.accessioned 2023-01-25T01:05:12Z
dc.date.available 2023-01-25T01:05:12Z
dc.date.issued 2022-11-22
dc.identifier.citation Frenzel , S , Bis , J C , Gudmundsson , E F , O'Donnell , A , Simino , J , Yaqub , A , Bartz , T M , Brusselle , G G O , Bülow , R , DeCarli , C S , Ewert , R , Gharib , S A , Ghosh , S , Gireud-Goss , M , Gottesman , R F , Ikram , M A , Knopman , D S , Launer , L J , London , S J , Longstreth , W T , Lopez , O L , Melo van Lent , D , O'Connor , G , Satizabal , C L , Shrestha , S , Sigurdsson , S , Stubbe , B , Talluri , R , Vasan , R S , Vernooij , M W , Völzke , H , Wiggins , K L , Yu , B , Beiser , A S , Gudnason , V , Mosley , T , Psaty , B M , Wolters , F J , Grabe , H J & Seshadri , S 2022 , ' Associations of Pulmonary Function with MRI Brain Volumes : A Coordinated Multi-Study Analysis ' , Journal of Alzheimer's disease : JAD , vol. 90 , no. 3 , pp. 1073-1083 . https://doi.org/10.3233/JAD-220667
dc.identifier.issn 1387-2877
dc.identifier.other PURE: 70305509
dc.identifier.other PURE UUID: 1d50fa72-2e78-45cf-9e43-a6339ce1725e
dc.identifier.other Scopus: 85142940876
dc.identifier.other unpaywall: 10.3233/jad-220667
dc.identifier.uri https://hdl.handle.net/20.500.11815/3895
dc.description This study was supported by National Institute of Health (NIH) grant AG059421. Additional study-specific acknowledgements can be found in the Supplementary Material.
dc.description.abstract BACKGROUND: Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent. OBJECTIVE: To study the cross-sectional associations of pulmonary function with structural brain variables. METHODS: Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities were investigated using multivariable linear regressions for each study separately and then combined using random-effect meta-analyses. RESULTS: FEV1 and FVC were positively associated with brain volume, gray matter volume, and hippocampal volume, and negatively associated with white matter hyperintensities volume after multiple testing correction, with little heterogeneity present between the studies. For instance, an increase of FVC by one unit was associated with 3.5 ml higher brain volume (95% CI: [2.2, 4.9]). In contrast, results for FEV1/FVC were more heterogeneous across studies, with significant positive associations with brain volume, gray matter volume, and hippocampal volume, but not white matter hyperintensities volume. Associations of brain variables with both FEV1 and FVC were consistently stronger than with FEV1/FVC, specifically with brain volume and white matter hyperintensities volume. CONCLUSION: In cross-sectional analyses, worse pulmonary function is associated with smaller brain volumes and higher white matter hyperintensities burden.
dc.format.extent 11
dc.format.extent 1073-1083
dc.language.iso en
dc.relation.ispartofseries Journal of Alzheimer's disease : JAD; 90(3)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Dementia
dc.subject epidemiology
dc.subject magnetic resonance imaging
dc.subject respiratory function tests
dc.subject Neuroscience (all)
dc.subject Clinical Psychology
dc.subject Geriatrics and Gerontology
dc.subject Psychiatry and Mental Health
dc.title Associations of Pulmonary Function with MRI Brain Volumes : A Coordinated Multi-Study Analysis
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 36213999
dc.identifier.doi https://doi.org/10.3233/JAD-220667
dc.relation.url http://www.scopus.com/inward/record.url?scp=85142940876&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine

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