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Pharmaceutical polymorph control in a drug-mimetic supramolecular gel

Pharmaceutical polymorph control in a drug-mimetic supramolecular gel


Titill: Pharmaceutical polymorph control in a drug-mimetic supramolecular gel
Höfundur: Foster, Jonathan A.
Damodoaran, Krishna   orcid.org/0000-0002-9741-2997
Maurin, Antoine
Day, Graeme M.
Thompson, Hugh P. G.
Cameron, Gary J.
Bernal, Jenifer Cuesta
Steed, Jonathan W.
Útgáfa: 2017
Tungumál: Enska
Umfang: 78-84
Háskóli/Stofnun: Háskóli Íslands
University of Iceland
Svið: Verkfræði- og náttúruvísindasvið (HÍ)
School of Engineering and Natural Sciences (UI)
Deild: Raunvísindastofnun (HÍ)
Science Institute (UI)
Birtist í: Chemical Science;8(1)
ISSN: 2041-6520
2041-6539 (eISSN)
DOI: 10.1039/c6sc04126d
URI: https://hdl.handle.net/20.500.11815/352

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Tilvitnun:

Foster, J. A., Damodaran, K. K., Maurin, A., Day, G. M., Thompson, H. P. G., Cameron, G. J., . . . Steed, J. W. (2017). Pharmaceutical polymorph control in a drug-mimetic supramolecular gel. Chemical Science, 8(1), 78-84. doi:10.1039/C6SC04126D

Útdráttur:

We report the synthesis of a bis(urea) gelator designed to specifically mimic the chemical structure of the highly polymorphic drug substance ROY. Crystallization of ROY from toluene gels of this gelator results in the formation of the metastable red form instead of the thermodynamic yellow polymorph. In contrast, all other gels and solution control experiments give the yellow form. Conformational and crystal structure prediction methods have been used to propose the structure of the gel and show that the templation of the red form by the targeted gel results from conformational matching of the gelator to the ROY substrate coupled with overgrowth of ROY onto the local periodic structure of the gel fibres.

Leyfi:

Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

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