Reproductive fitness and genetic risk of psychiatric disorders in the general population

Mullins, Niamh; Ingason, Andrés; Porter, Heather; Euesden, Jack; Gillett, Alexandra; Ólafsson, Sigurgeir; Gudbjartsson, Daniel; Lewis, Cathryn M.; Sigurdsson, Engilbert; Sæmundsen, Evald E.; Guðmundsson, Ólafur Ó.; Frigge, Michael L.; Kong, Augustine; Helgason, Agnar; Walters, G. Bragi; Gústafsson, Ómar; Stefánsson, Hreinn; Stefansson, Kari

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dc.contributor	Háskóli Íslands
dc.contributor	University of Iceland
dc.contributor.author	Mullins, Niamh
dc.contributor.author	Ingason, Andrés
dc.contributor.author	Porter, Heather
dc.contributor.author	Euesden, Jack
dc.contributor.author	Gillett, Alexandra
dc.contributor.author	orcid.org/0000-0003-1711-2757 Ólafsson, Sigurgeir
dc.contributor.author	Gudbjartsson, Daniel
dc.contributor.author	Lewis, Cathryn M.
dc.contributor.author	Sigurdsson, Engilbert
dc.contributor.author	Sæmundsen, Evald E.
dc.contributor.author	Guðmundsson, Ólafur Ó.
dc.contributor.author	Frigge, Michael L.
dc.contributor.author	Kong, Augustine
dc.contributor.author	Helgason, Agnar
dc.contributor.author	orcid.org/0000-0002-5415-6487 Walters, G. Bragi
dc.contributor.author	Gústafsson, Ómar
dc.contributor.author	Stefánsson, Hreinn
dc.contributor.author	orcid.org/0000-0003-1676-864X Stefansson, Kari
dc.date.accessioned	2017-07-06T14:12:52Z
dc.date.available	2017-07-06T14:12:52Z
dc.date.issued	2017-06-13
dc.identifier.citation	Mullins, N. et al. Reproductive fitness and genetic risk for psychiatric disorders in the general population. Nat. Commun. 8, 15833 doi: 10.1038/ncomms15833 (2017).
dc.identifier.issn	2041-1723
dc.identifier.uri	https://hdl.handle.net/20.500.11815/319
dc.description.abstract	The persistence of common, heritable psychiatric disorders that reduce reproductive fitness is an evolutionary paradox. Here, we investigate the selection pressures on sequence variants that predispose to schizophrenia, autism, bipolar disorder, major depression and attention deficit hyperactivity disorder (ADHD) using genomic data from 150,656 Icelanders, excluding those diagnosed with these psychiatric diseases. Polygenic risk of autism and ADHD is associated with number of children. Higher polygenic risk of autism is associated with fewer children and older age at first child whereas higher polygenic risk of ADHD is associated with having more children. We find no evidence for a selective advantage of a high polygenic risk of schizophrenia or bipolar disorder. Rare copy-number variants conferring moderate to high risk of psychiatric illness are associated with having fewer children and are under stronger negative selection pressure than common sequence variants.
dc.description.sponsorship	The authors are grateful to the participants and we thank the research nurses and staff at the Krokhals recruitment centre. We also thank the staff at deCODE genetics core facilities for their important contribution to this work. The research leading to these results has received support from the European Community's Seventh Framework Programme under the Marie Curie Industry-Academia Partnership and Pathways (PsychDPC, GA 286213), the Innovative Medicines Initiative Joint Undertaking under grant agreement 115008 and in part by the National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London.
dc.format.extent	15833
dc.language.iso	en
dc.publisher	Springer Nature
dc.relation	info:eu-repo/grantAgreement/EC/FP7/GA 286213
dc.relation.ispartofseries	Nature Communications;8
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Autism spectrum disorders
dc.subject	Evolutionary biology
dc.subject	Genetic association study
dc.subject	Einhverfa
dc.subject	Félagslíffræði
dc.subject	Erfðafræði
dc.subject	Rannsóknir
dc.title	Reproductive fitness and genetic risk of psychiatric disorders in the general population
dc.type	info:eu-repo/semantics/article
dcterms.license	Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
dc.description.version	Peer Reviewed
dc.identifier.journal	Nature Communications
dc.identifier.doi	doi:10.1038/ncomms15833
dc.relation.url	https://www.nature.com/articles/ncomms15833
dc.contributor.department	Læknadeild (HÍ)
dc.contributor.department	Faculty of Medicine (UI)
dc.contributor.department	Félags- og mannvísindadeild (HÍ)
dc.contributor.department	Faculty of Social and Human Sciences (UI)
dc.contributor.school	Heilbrigðisvísindasvið (HÍ)
dc.contributor.school	School of Health Sciences (UI)
dc.contributor.school	Félagsvísindasvið (HÍ)
dc.contributor.school	School of Social Sciences (UI)