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International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease
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| Title: | International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease |
| Author: | |
| Date: | 2022-02-11 |
| Language: | English |
| Scope: | 7 |
| Department: | Other departments Clinical Laboratory Services, Diagnostics and Blood Bank Faculty of Medicine |
| Series: | Vaccine; 40(7) |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2021.10.046 |
| Subject: | Sýklafræði; Náttúrufræðingar; Disease Outbreaks; Finland; Genome, Bacterial; Humans; Northern Ireland; Norway; Occupational Exposure; Phylogeny; Pneumococcal Infections/epidemiology; Polymorphism, Single Nucleotide; Serogroup; Serotyping; Ships; Streptococcus pneumoniae |
| URI: | https://hdl.handle.net/20.500.11815/3080 |
Citation:The Global Pneumococcal Sequencing Consortium 2022 , ' International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease ' , Vaccine , vol. 40 , no. 7 , pp. 1054-1060 . https://doi.org/10.1016/j.vaccine.2021.10.046
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Abstract:Background: Pneumococcal disease outbreaks of vaccine preventable serotype 4 sequence type (ST)801 in shipyards have been reported in several countries. We aimed to use genomics to establish any international links between them. Methods: Sequence data from ST801-related outbreak isolates from Norway (n = 17), Finland (n = 11) and Northern Ireland (n = 2) were combined with invasive pneumococcal disease surveillance from the respective countries, and ST801-related genomes from an international collection (n = 41 of > 40,000), totalling 106 genomes. Raw data were mapped and recombination excluded before phylogenetic dating. Results: Outbreak isolates were relatively diverse, with up to 100 SNPs (single nucleotide polymorphisms) and a common ancestor estimated around the year 2000. However, 19 Norwegian and Finnish isolates were nearly indistinguishable (0–2 SNPs) with the common ancestor dated around 2017. Conclusion: The total diversity of ST801 within the outbreaks could not be explained by recent transmission alone, suggesting that harsh environmental and associated living conditions reported in the shipyards may facilitate invasion of colonising pneumococci. However, near identical strains in the Norwegian and Finnish outbreaks does suggest that transmission between international shipyards also contributed to those outbreaks. This indicates the need for improved preventative measures in this working population including pneumococcal vaccination.
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Description:Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved. Funding Information: We would like to acknowledge the Global Pneumococcal Sequencing project (GPS) and other pneumococcal sequencing projects performed at the Wellcome Sanger Institute whose genomes were screened to identify isolates that could provide context for this analysis, and the Wellcome Sanger Institute Pathogen Informatics Team. The GPS data was supported by the Wellcome Trust, grant number 206194/Z/17/Z, and by the Bill and Melinda Gates Foundation, Investment ID INV-003570. Furthermore, we acknowledge Lene Kolstad, Martha Bjørnstad and Nadia Debech of the Norwegian Institute of Public Health for the analysis of the Norwegian isolates, Brita A Winje for the Norwegian IPD surveillance data and the rest of the outbreak team for their work during the outbreak. We would like to acknowledge Anni Vainio, Milla Hietikko, Elina Yamazaki and Riitta Pulkkinen for laboratory and sequencing work of the Finnish isolates and the outbreak investigation team for their work to control the outbreak. The findings and conclusions in this manuscript are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Sequencing of outbreak and contemporary IPD surveillance isolates were funded internally in the respective public health institutes. The Global Pneumococcal Sequencing project was funded by Wellcome Trust, grant number 206194/Z/17/Z, and by the Bill and Melinda Gates Foundation, Investment ID INV-003570. J.C. was funded by the European Research Council grant no. 742158. PT is funded by the Wellcome Trust (Thailand-Laos AAP core award, grant no. 220211). Funding Information: We would like to acknowledge the Global Pneumococcal Sequencing project (GPS) and other pneumococcal sequencing projects performed at the Wellcome Sanger Institute whose genomes were screened to identify isolates that could provide context for this analysis, and the Wellcome Sanger Institute Pathogen Informatics Team. The GPS data was supported by the Wellcome Trust, grant number 206194/Z/17/Z, and by the Bill and Melinda Gates Foundation, Investment ID INV-003570. Furthermore, we acknowledge Lene Kolstad, Martha Bjørnstad and Nadia Debech of the Norwegian Institute of Public Health for the analysis of the Norwegian isolates, Brita A Winje for the Norwegian IPD surveillance data and the rest of the outbreak team for their work during the outbreak. Funding Information: Sequencing of outbreak and contemporary IPD surveillance isolates were funded internally in the respective public health institutes. The Global Pneumococcal Sequencing project was funded by Wellcome Trust, grant number 206194/Z/17/Z, and by the Bill and Melinda Gates Foundation, Investment ID INV-003570. J.C. was funded by the European Research Council grant no. 742158. PT is funded by the Wellcome Trust (Thailand-Laos AAP core award, grant no. 220211). Publisher Copyright: © 2021 The Author(s)
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