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International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author The Global Pneumococcal Sequencing Consortium
dc.date.accessioned 2022-04-26T01:03:50Z
dc.date.available 2022-04-26T01:03:50Z
dc.date.issued 2022-02-11
dc.identifier.citation The Global Pneumococcal Sequencing Consortium 2022 , ' International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease ' , Vaccine , vol. 40 , no. 7 , pp. 1054-1060 . https://doi.org/10.1016/j.vaccine.2021.10.046
dc.identifier.issn 0264-410X
dc.identifier.other PURE: 45108717
dc.identifier.other PURE UUID: 8e7157d3-28bd-4c7f-8895-bea099978275
dc.identifier.other Scopus: 85122325554
dc.identifier.other WOSLite: 000750903800013
dc.identifier.uri https://hdl.handle.net/20.500.11815/3080
dc.description Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
dc.description.abstract Background: Pneumococcal disease outbreaks of vaccine preventable serotype 4 sequence type (ST)801 in shipyards have been reported in several countries. We aimed to use genomics to establish any international links between them. Methods: Sequence data from ST801-related outbreak isolates from Norway (n = 17), Finland (n = 11) and Northern Ireland (n = 2) were combined with invasive pneumococcal disease surveillance from the respective countries, and ST801-related genomes from an international collection (n = 41 of > 40,000), totalling 106 genomes. Raw data were mapped and recombination excluded before phylogenetic dating. Results: Outbreak isolates were relatively diverse, with up to 100 SNPs (single nucleotide polymorphisms) and a common ancestor estimated around the year 2000. However, 19 Norwegian and Finnish isolates were nearly indistinguishable (0–2 SNPs) with the common ancestor dated around 2017. Conclusion: The total diversity of ST801 within the outbreaks could not be explained by recent transmission alone, suggesting that harsh environmental and associated living conditions reported in the shipyards may facilitate invasion of colonising pneumococci. However, near identical strains in the Norwegian and Finnish outbreaks does suggest that transmission between international shipyards also contributed to those outbreaks. This indicates the need for improved preventative measures in this working population including pneumococcal vaccination.
dc.format.extent 7
dc.format.extent 1054-1060
dc.language.iso en
dc.relation.ispartofseries Vaccine; 40(7)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Sýklafræði
dc.subject Náttúrufræðingar
dc.subject Disease Outbreaks
dc.subject Finland
dc.subject Genome, Bacterial
dc.subject Humans
dc.subject Northern Ireland
dc.subject Norway
dc.subject Occupational Exposure
dc.subject Phylogeny
dc.subject Pneumococcal Infections/epidemiology
dc.subject Polymorphism, Single Nucleotide
dc.subject Serogroup
dc.subject Serotyping
dc.subject Ships
dc.subject Streptococcus pneumoniae
dc.title International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 34996643
dc.identifier.doi https://doi.org/10.1016/j.vaccine.2021.10.046
dc.relation.url http://www.scopus.com/inward/record.url?scp=85122325554&partnerID=8YFLogxK
dc.contributor.department Clinical Laboratory Services, Diagnostics and Blood Bank
dc.contributor.department Faculty of Medicine


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