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International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease

International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease


Title: International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease
Author: The Global Pneumococcal Sequencing Consortium
Date: 2022-02-11
Language: English
Scope: 7
University/Institute: Landspitali - The National University Hospital of Iceland
Department: Clinical Laboratory Services, Diagnostics and Blood Bank
Faculty of Medicine
Series: Vaccine; 40(7)
ISSN: 0264-410X
DOI: https://doi.org/10.1016/j.vaccine.2021.10.046
Subject: Sýklafræði; Náttúrufræðingar; Disease Outbreaks; Finland; Genome, Bacterial; Humans; Northern Ireland; Norway; Occupational Exposure; Phylogeny; Pneumococcal Infections/epidemiology; Polymorphism, Single Nucleotide; Serogroup; Serotyping; Ships; Streptococcus pneumoniae
URI: https://hdl.handle.net/20.500.11815/3080

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Citation:

The Global Pneumococcal Sequencing Consortium 2022 , ' International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease ' , Vaccine , vol. 40 , no. 7 , pp. 1054-1060 . https://doi.org/10.1016/j.vaccine.2021.10.046

Abstract:

Background: Pneumococcal disease outbreaks of vaccine preventable serotype 4 sequence type (ST)801 in shipyards have been reported in several countries. We aimed to use genomics to establish any international links between them. Methods: Sequence data from ST801-related outbreak isolates from Norway (n = 17), Finland (n = 11) and Northern Ireland (n = 2) were combined with invasive pneumococcal disease surveillance from the respective countries, and ST801-related genomes from an international collection (n = 41 of > 40,000), totalling 106 genomes. Raw data were mapped and recombination excluded before phylogenetic dating. Results: Outbreak isolates were relatively diverse, with up to 100 SNPs (single nucleotide polymorphisms) and a common ancestor estimated around the year 2000. However, 19 Norwegian and Finnish isolates were nearly indistinguishable (0–2 SNPs) with the common ancestor dated around 2017. Conclusion: The total diversity of ST801 within the outbreaks could not be explained by recent transmission alone, suggesting that harsh environmental and associated living conditions reported in the shipyards may facilitate invasion of colonising pneumococci. However, near identical strains in the Norwegian and Finnish outbreaks does suggest that transmission between international shipyards also contributed to those outbreaks. This indicates the need for improved preventative measures in this working population including pneumococcal vaccination.

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Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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