Titill: | Prenatal Maternal Bereavement and Its Association With Intellectual Disability in the Offspring |
Höfundur: |
|
Útgáfa: | 2021-10-01 |
Tungumál: | Enska |
Umfang: | 7 |
Deild: | Faculty of Medicine |
Birtist í: | Psychosomatic Medicine; 83(8) |
ISSN: | 0033-3174 |
DOI: | 10.1097/PSY.0000000000000990 |
Efnisorð: | Greindarskerðing; Ástvinamissir; Meðganga; Danmörk; Danmörk; Bereavement; Intellectual disability; Prenatal exposure; Denmark; Cohort study; Prenatal Exposure Delayed Effects/epidemiology; Grief; Humans; Risk Factors; Male; Intellectual Disability/epidemiology; Pregnancy; Denmark/epidemiology; Adolescent; Female; Registries; Child; Cohort Studies; Psychiatry and Mental Health; Applied Psychology |
URI: | https://hdl.handle.net/20.500.11815/3060 |
Tilvitnun:Su , X , Yu , Y , Meng , L , Duan , T , Zhao , Y , László , K D , Valdimarsdóttir , U A , Hua , J & Li , J 2021 , ' Prenatal Maternal Bereavement and Its Association With Intellectual Disability in the Offspring ' , Psychosomatic Medicine , vol. 83 , no. 8 , pp. 887-893 . https://doi.org/10.1097/PSY.0000000000000990
|
|
Útdráttur:OBJECTIVE: This study aimed to examine the association of a mother's loss of a close relative before or during pregnancy with intellectual disability (ID) in the offspring. METHODS: We performed a nationwide population-based cohort study based on Danish national registries. All live-born singletons born in Denmark during the 1978-2016 period (n = 2,216,601) were followed up starting from birth to 38 years of age. Log-linear Poisson regression was used to estimate the association between maternal bereavement (the death of an older child, a partner, or a parent 1 year before or during pregnancy) and the risk of ID in the offspring. RESULTS: Maternal bereavement during or before pregnancy was associated with an increased risk of ID (incidence rate ratio [IRR] = 1.15; 95% confidence interval [CI] = 1.04-1.28). The risk of ID was increased by 27% when maternal bereavement occurred during pregnancy (IRR = 1.27; 95% CI = 1.08-1.49). When stratifying on the child's sex, we also observed an increased risk of ID associated with maternal bereavement during pregnancy both for male (IRR = 1.25; 95% CI = 1.02-1.53) and for female (IRR = 1.31; 95% CI = 1.02-1.69), respectively. The IRRs for unnatural death of a relative were also elevated (IRR = 1.22; 95% CI = 0.91-1.64) in general, although the difference was not statistically significant. CONCLUSIONS: Our findings suggest that prenatal stress due to maternal loss of a close relative may increase the risk of offspring's ID of both sexes, in particular when the loss happened during pregnancy.
|
|
Athugasemdir:Source of Funding and Conflicts of Interest: X.S. is currently receiving a grant from the National Natural Science Foundation of China (81602860). Y.Y. is currently receiving a grant from the Lundbeck Foundation (R232-2016-2462 and R265-2017-4069). K.D.L. is currently receiving a grant from the Swedish Council for Working Life and Social Research (2015-00837). The study was supported by grants from the Independent Research Fund Denmark (DFF-6110-00019B and DFF-9039-00010B), the National Nature Science Foundation of China (82073570), the Nordic Cancer Union (R275-A15770), the Karen Elise Jensens Fond (2016), and the Novo Nordisk Foundation (NNF18OC0052029). All authors declare that there are no conflicts of interest. Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Psychosomatic Society.
|