dc.contributor.author |
Su, Xiujuan |
dc.contributor.author |
Yu, Yongfu |
dc.contributor.author |
Meng, Lulu |
dc.contributor.author |
Duan, Tony |
dc.contributor.author |
Zhao, Yan |
dc.contributor.author |
László, Krisztina D. |
dc.contributor.author |
Valdimarsdóttir, Unnur Anna |
dc.contributor.author |
Hua, Jing |
dc.contributor.author |
Li, Jiong |
dc.date.accessioned |
2022-04-14T01:02:17Z |
dc.date.available |
2022-04-14T01:02:17Z |
dc.date.issued |
2021-10-01 |
dc.identifier.citation |
Su , X , Yu , Y , Meng , L , Duan , T , Zhao , Y , László , K D , Valdimarsdóttir , U A , Hua , J & Li , J 2021 , ' Prenatal Maternal Bereavement and Its Association With Intellectual Disability in the Offspring ' , Psychosomatic Medicine , vol. 83 , no. 8 , pp. 887-893 . https://doi.org/10.1097/PSY.0000000000000990 |
dc.identifier.issn |
0033-3174 |
dc.identifier.other |
41779925 |
dc.identifier.other |
df2e4f22-56bf-46f3-86b8-c6a726b09d89 |
dc.identifier.other |
85118096356 |
dc.identifier.other |
34334730 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/3060 |
dc.description |
Source of Funding and Conflicts of Interest: X.S. is currently receiving a grant from the National Natural Science Foundation of China (81602860). Y.Y. is currently receiving a grant from the Lundbeck Foundation (R232-2016-2462 and R265-2017-4069). K.D.L. is currently receiving a grant from the Swedish Council for Working Life and Social Research (2015-00837). The study was supported by grants from the Independent Research Fund Denmark (DFF-6110-00019B and DFF-9039-00010B), the National Nature Science Foundation of China (82073570), the Nordic Cancer Union (R275-A15770), the Karen Elise Jensens Fond (2016), and the Novo Nordisk Foundation (NNF18OC0052029). All authors declare that there are no conflicts of interest. Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Psychosomatic Society. |
dc.description.abstract |
OBJECTIVE: This study aimed to examine the association of a mother's loss of a close relative before or during pregnancy with intellectual disability (ID) in the offspring. METHODS: We performed a nationwide population-based cohort study based on Danish national registries. All live-born singletons born in Denmark during the 1978-2016 period (n = 2,216,601) were followed up starting from birth to 38 years of age. Log-linear Poisson regression was used to estimate the association between maternal bereavement (the death of an older child, a partner, or a parent 1 year before or during pregnancy) and the risk of ID in the offspring. RESULTS: Maternal bereavement during or before pregnancy was associated with an increased risk of ID (incidence rate ratio [IRR] = 1.15; 95% confidence interval [CI] = 1.04-1.28). The risk of ID was increased by 27% when maternal bereavement occurred during pregnancy (IRR = 1.27; 95% CI = 1.08-1.49). When stratifying on the child's sex, we also observed an increased risk of ID associated with maternal bereavement during pregnancy both for male (IRR = 1.25; 95% CI = 1.02-1.53) and for female (IRR = 1.31; 95% CI = 1.02-1.69), respectively. The IRRs for unnatural death of a relative were also elevated (IRR = 1.22; 95% CI = 0.91-1.64) in general, although the difference was not statistically significant. CONCLUSIONS: Our findings suggest that prenatal stress due to maternal loss of a close relative may increase the risk of offspring's ID of both sexes, in particular when the loss happened during pregnancy. |
dc.format.extent |
7 |
dc.format.extent |
182242 |
dc.format.extent |
887-893 |
dc.language.iso |
en |
dc.relation.ispartofseries |
Psychosomatic Medicine; 83(8) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Greindarskerðing |
dc.subject |
Ástvinamissir |
dc.subject |
Meðganga |
dc.subject |
Danmörk |
dc.subject |
Danmörk |
dc.subject |
Bereavement |
dc.subject |
Intellectual disability |
dc.subject |
Prenatal exposure |
dc.subject |
Denmark |
dc.subject |
Cohort study |
dc.subject |
Prenatal Exposure Delayed Effects/epidemiology |
dc.subject |
Grief |
dc.subject |
Humans |
dc.subject |
Risk Factors |
dc.subject |
Male |
dc.subject |
Intellectual Disability/epidemiology |
dc.subject |
Pregnancy |
dc.subject |
Denmark/epidemiology |
dc.subject |
Adolescent |
dc.subject |
Female |
dc.subject |
Registries |
dc.subject |
Child |
dc.subject |
Cohort Studies |
dc.subject |
Psychiatry and Mental Health |
dc.subject |
Applied Psychology |
dc.title |
Prenatal Maternal Bereavement and Its Association With Intellectual Disability in the Offspring |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.1097/PSY.0000000000000990 |
dc.relation.url |
http://www.scopus.com/inward/record.url?scp=85118096356&partnerID=8YFLogxK |
dc.contributor.department |
Faculty of Medicine |