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Fletta eftir efnisorði "Drug Discovery"

Fletta eftir efnisorði "Drug Discovery"

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  • Hrólfsdóttir, Anna Þóra; Arason, Sigurjón; Sveinsdóttir, Hildur Inga; Gudjónsdóttir, María (2022-05-24)
    Ascophyllum nodosum contains many valuable compounds, including polyphenols, peptides, and carotenoids that have been shown to exhibit biological activities. These compounds are not a priority ingredient in seaweed meal products for the current users. ...
  • Karvelsson, Sigurður Trausti; Wang, Qiong; Hilmarsdóttir, Bylgja; Sigurðsson, Arnar; Moestue, Siver Andreas; Mælandsmo, Gunhild Mari; Halldórsson, Skarphédinn; Guðmundsson, Steinn; Rolfsson, Óttar (2021-09-17)
    Epithelial-to-mesenchymal transition (EMT) is fundamental to both normal tissue development and cancer progression. We hypothesized that EMT plasticity defines a range of metabolic phenotypes and that individual breast epithelial metabolic phenotypes ...
  • Vesco, Guglielmo; Brambati, Martino; Scapinello, Luca; Penoni, Andrea; Mella, Massimo; Masson, Màr; Gaware, Vivek; Maspero, Angelo; Nardo, Luca (2022-07-09)
    Curcumin has been demonstrated to exhibit photosensitized bactericidal activity. However, the full exploitation of curcumin as a photo-pharmaceutical active principle is hindered by fast deactivation of the excited state through the transfer of the ...
  • Sigurjónsson, Svanur; Haraldsson, Gudmundur G. (2024-01)
    The asymmetric synthesis of polyunsaturated triene C18:3 n-3 and C18:3 n-6 methoxylated ether lipids (MEL) of the 1-O-alkyl-sn-glycerol type is described as possible structural candidates for a triene C18:3 MEL of an unknown identity found in a mixture ...
  • Kallab, Martin; Schuetzenberger, Kornelia; Hommer, Nikolaus; Schäfer, Bhavapriya Jasmin; Schmidl, Doreen; Bergmeister, Helga; Zeitlinger, Markus; Tan, Aimin; Jansook, Phatsawee; Loftsson, Þorsteinn; Stefánsson, Einar; Garhöfer, Gerhard (2021-05-18)
    The purpose of this study was to evaluate the ocular pharmacokinetics, bio-distribution and local tolerability of γ-cyclodextrin (γCD) based irbesartan 1.5% eye drops and candesartan 0.15% eye drops after single and multiple topical administration in ...
  • Eiríksdóttir, Heiðrún; Stefánsson, Magnús Örn; Einarsson, Hjörleifur (2021)
    The demand for novel sources of marine oils, which contain polyunsaturated fatty acids (PUFAs), has increased due to the realization of the importance of PUFAs, e.g., docosahexaenoic acid (DHA), in the human diet. However, the natural supply is limited. ...
  • Björnsson, Einar Stefán (2024-04)
    The incidence and prevalence of drug-induced liver injury appear to be increasing globally, for example, with the introduction of checkpoint inhibitors. Several reviews have been published in the last decade on the epidemiology of DILI, both among ...
  • Castejón, Natalia; Þórarinsdóttir, Kristín Anna; Einarsdóttir, Ragnhildur; Kristbergsson, Kristberg; Marteinsdóttir, Guðrún (2021-11-25)
    A growing concern for overall health is driving a global market of natural ingredients not only in the food industry but also in the cosmetic field. In this study, a screening on potential cosmetic applications of aqueous extracts from three Icelandic ...
  • Di, Xiaxia; Harðardóttir, Ingibjörg; Freysdóttir, Jóna; Wang, Dongdong; Gustafson, Kirk R; Ómarsdóttir, Sesselja Sigurborg; Molinski, Tadeusz F (2023-04)
    Geobarrettin D (1), a new bromoindole alkaloid, was isolated from the marine sponge Geodia barretti collected from Icelandic waters. Its structure was elucidated by 1D, and 2D NMR (including 1H-15N HSQC, 1H-15N HMBC spectra), as well as HRESIMS data. ...
  • Bokan, Goran; Glamočanin, Tanja; Mavija, Zoran; Vidović, Bojana; Stojanović, Ana; Björnsson, Einar Stefán; Vučić, Vesna (2023-08-10)
    Herb-induced liver injury (HILI) caused by herbal supplements, natural products, and products used in traditional medicine are important for differential diagnoses in patients with acute liver injury without an obvious etiology. The root of Withania ...
  • Helgadottir, Holmfridur; Björnsson, Einar Stefán (2023-12)
    Proton pump inhibitor (PPI) treatment is responsible for substantial gastrin elevation secondary to reduced intragastric acidity. Due to the increasing global prevalence of PPI users, concerns have been raised about the clinical significance of continuous ...
  • Viktorsson, Elvar Örn; Aesoy, Reidun; Støa, Sindre; Lekve, Viola; Døskeland, Stein Ove; Herfindal, Lars; Rongved, Pål (2021-05)
    Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin ( 3) and myxin ( 4) exhibit potent and hypoxia-selective cell death on ...
  • PRECISEQ Consortium; FinnGen Consortium; NINDS Stroke Genetics Network (SiGN); MEGASTROKE Consortium; SIREN Consortium; China Kadoorie Biobank Collaborative Group; VA Million Veteran Program; International Stroke Genetics Consortium (ISGC); Biobank Japan; CHARGE consortium.; GIGASTROKE Consortium; COMPASS Consortium; INVENT Consortium; Dutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study Group; Estonian Biobank (2022-09-30)
    Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had ...
  • Urimi, Dileep; Hellsing, Maja; Mahmoudi, Najet; Söderberg, Christopher; Widenbring, Ronja; Gedda, Lars; Edwards, Katarina; Loftsson, Thorsteinn; Schipper, Nicolaas (2022-02-28)
    Lipid nanocapsules (LNCs) are increasingly being used for various drug delivery applications due to their versatile nature and ability to carry a wide variety of therapeutic drug molecules. In the present investigation, small-angle X-ray (SAXS) and ...
  • Dillard, Pierre; Köksal, Hakan; Maggadóttir, Sólrún Melkorka; Winge-Main, Anna; Pollmann, Sylvie; Menard, Mathilde; Myhre, Marit Renée; Mælandsmo, Gunhild M.; Flørenes, Vivi Ann; Gaudernack, Gustav; Kvalheim, Gunnar; Wälchli, Sébastien; Inderberg, Else Marit (2021-03-03)
    T cell receptor (TCR)-engineered T cell therapy is a promising cancer treatment approach. Human telomerase reverse transcriptase (hTERT) is overexpressed in the majority of tumors and a potential target for adoptive cell therapy. We isolated a novel ...
  • Maggadóttir, Sólrún Melkorka; Dueland, Svein; Mensali, Nadia; Hamre, Hanne; Andresen, Per Arne; Myhre, Marit Renée; Juul, Hedvig V.; Bigalke, Iris; Lundby, Marianne; Hønnåshagen, Turid Kirsti; Sæbøe-Larssen, Stein; Josefsen, Dag; Hagtvedt, Trond; Wälchli, Sébastien; Kvalheim, Gunnar; Inderberg, Else Marit (2024-06-05)
    We previously demonstrated the antitumor effectiveness of transiently T cell receptor (TCR)-redirected T cells recognizing a frameshift mutation in transforming growth factor beta receptor 2. We here describe a clinical protocol using mRNA TCR-modified ...