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Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti

Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti

Title: Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti
Author: Di, Xiaxia
Harðardóttir, Ingibjörg
Freysdóttir, Jóna
Wang, Dongdong
Gustafson, Kirk R
Ómarsdóttir, Sesselja Sigurborg
Molinski, Tadeusz F
Date: 2023-04
Language: English
Scope:
Department: Faculty of Medicine
Clinical Laboratory Services, Diagnostics and Blood Bank
Other departments
Faculty of Pharmaceutical Sciences
Series: Molecules; 28(7)
ISSN: 1420-3049
DOI: https://doi.org/10.3390/molecules28072937
Subject: Náttúrufræðingar; Animals; Humans; Geodia/chemistry; Alkaloids/pharmacology; Cytokines; Anti-Inflammatory Agents; Molecular Structure; dendritic cells; Geodia barretti; herbipoline; 6-bromoindole; anti-inflammatory activity; Drug Discovery; Analytical Chemistry; Chemistry (miscellaneous); Molecular Medicine; Physical and Theoretical Chemistry; Pharmaceutical Science; Organic Chemistry
URI: https://hdl.handle.net/20.500.11815/4152

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Citation:

Di , X , Harðardóttir , I , Freysdóttir , J , Wang , D , Gustafson , K R , Ómarsdóttir , S S & Molinski , T F 2023 , ' Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti ' , Molecules , vol. 28 , no. 7 , 2937 . https://doi.org/10.3390/molecules28072937

Abstract:

Geobarrettin D (1), a new bromoindole alkaloid, was isolated from the marine sponge Geodia barretti collected from Icelandic waters. Its structure was elucidated by 1D, and 2D NMR (including 1H-15N HSQC, 1H-15N HMBC spectra), as well as HRESIMS data. Geobarrettin D (1) is a new 6-bromoindole featuring an unusual purinium herbipoline moiety. Geobarrettin D (1) decreased secretion of the pro-inflammatory cytokine IL-12p40 by human monocyte derived dendritic cells, without affecting secretion of the anti-inflammatory cytokine IL-10. Thus, compound 1 shows anti-inflammatory activity.

Description:

Funding Information: This research was funded by University of Iceland Research Fund (Doctoral Grant and Project Grant), grant numbers not available, AVS R&D Fund of Ministry of Fisheries and Agriculture in Iceland, grant number R 029-14, the Landspitali University Hospital Research Fund (grant number not available), and the National Institutes of Health (AI100776, AT009783, to T.F.M.). Publisher Copyright: © 2023 by the authors.

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