dc.contributor.author |
Di, Xiaxia |
dc.contributor.author |
Harðardóttir, Ingibjörg |
dc.contributor.author |
Freysdóttir, Jóna |
dc.contributor.author |
Wang, Dongdong |
dc.contributor.author |
Gustafson, Kirk R |
dc.contributor.author |
Ómarsdóttir, Sesselja Sigurborg |
dc.contributor.author |
Molinski, Tadeusz F |
dc.date.accessioned |
2023-04-22T01:05:05Z |
dc.date.available |
2023-04-22T01:05:05Z |
dc.date.issued |
2023-04 |
dc.identifier.citation |
Di , X , Harðardóttir , I , Freysdóttir , J , Wang , D , Gustafson , K R , Ómarsdóttir , S S & Molinski , T F 2023 , ' Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti ' , Molecules , vol. 28 , no. 7 , 2937 . https://doi.org/10.3390/molecules28072937 |
dc.identifier.issn |
1420-3049 |
dc.identifier.other |
122052833 |
dc.identifier.other |
9d36d9fc-e082-4514-a9e3-617c38a76941 |
dc.identifier.other |
37049700 |
dc.identifier.other |
PubMedCentral: PMC10095911 |
dc.identifier.other |
85152332899 |
dc.identifier.other |
unpaywall: 10.3390/molecules28072937 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/4152 |
dc.description |
Funding Information: This research was funded by University of Iceland Research Fund (Doctoral Grant and Project Grant), grant numbers not available, AVS R&D Fund of Ministry of Fisheries and Agriculture in Iceland, grant number R 029-14, the Landspitali University Hospital Research Fund (grant number not available), and the National Institutes of Health (AI100776, AT009783, to T.F.M.). Publisher Copyright: © 2023 by the authors. |
dc.description.abstract |
Geobarrettin D (1), a new bromoindole alkaloid, was isolated from the marine sponge Geodia barretti collected from Icelandic waters. Its structure was elucidated by 1D, and 2D NMR (including 1H-15N HSQC, 1H-15N HMBC spectra), as well as HRESIMS data. Geobarrettin D (1) is a new 6-bromoindole featuring an unusual purinium herbipoline moiety. Geobarrettin D (1) decreased secretion of the pro-inflammatory cytokine IL-12p40 by human monocyte derived dendritic cells, without affecting secretion of the anti-inflammatory cytokine IL-10. Thus, compound 1 shows anti-inflammatory activity. |
dc.format.extent |
1045055 |
dc.format.extent |
|
dc.language.iso |
en |
dc.relation.ispartofseries |
Molecules; 28(7) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Náttúrufræðingar |
dc.subject |
Animals |
dc.subject |
Humans |
dc.subject |
Geodia/chemistry |
dc.subject |
Alkaloids/pharmacology |
dc.subject |
Cytokines |
dc.subject |
Anti-Inflammatory Agents |
dc.subject |
Molecular Structure |
dc.subject |
dendritic cells |
dc.subject |
Geodia barretti |
dc.subject |
herbipoline |
dc.subject |
6-bromoindole |
dc.subject |
anti-inflammatory activity |
dc.subject |
Drug Discovery |
dc.subject |
Analytical Chemistry |
dc.subject |
Chemistry (miscellaneous) |
dc.subject |
Molecular Medicine |
dc.subject |
Physical and Theoretical Chemistry |
dc.subject |
Pharmaceutical Science |
dc.subject |
Organic Chemistry |
dc.title |
Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.3390/molecules28072937 |
dc.relation.url |
http://www.scopus.com/inward/record.url?scp=85152332899&partnerID=8YFLogxK |
dc.contributor.department |
Faculty of Medicine |
dc.contributor.department |
Clinical Laboratory Services, Diagnostics and Blood Bank |
dc.contributor.department |
Other departments |
dc.contributor.department |
Faculty of Pharmaceutical Sciences |