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Serum 25-hydroxyvitamin D concentrations in 16-year-old Icelandic adolescent and its association with bone mineral density

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Gudmundsdottir, Sigridur Lara
dc.contributor.author Hrafnkelsson, Hrafn
dc.contributor.author Sigurdsson, Engilbert
dc.contributor.author Johannsson, Erlingur
dc.date.accessioned 2021-01-11T14:56:09Z
dc.date.available 2021-01-11T14:56:09Z
dc.date.issued 2020-03-19
dc.identifier.citation Gudmundsdottir, S., Hrafnkelsson, H., Sigurdsson, E., & Johannsson, E. (2020). Serum 25-hydroxyvitamin D concentrations in 16-year-old Icelandic adolescent and its association with bone mineral density. Public Health Nutrition, 23(8), 1329-1333. doi:10.1017/S1368980019004142
dc.identifier.issn 1368-9800
dc.identifier.issn 1475-2727 (eISSN)
dc.identifier.uri https://hdl.handle.net/20.500.11815/2346
dc.description Publisher's version (útgefin grein)
dc.description.abstract Objective: The aim of the study was to assess the potential association between serum 25-hydroxyvitamin D (25(OH)D) and whole-body bone mineral density (BMD) among 16-year-old adolescents and to study the prevalence of 25(OH)D insufficiency, defined as concentration under 50 nmol/l.Design: A cross-sectional study.Setting: Reykjavik, Iceland, latitude 64°08′N. Measurements took place in the Icelandic Heart Association's research lab during April-June 2015.Participants: In total, 411 students in Reykjavik, Iceland, were invited to participate, 315 accepted the invitation (76·6 %) and 289 had valid data (mainly Caucasian).Results: 25(OH)D < 50 nmol/l was observed in 70 % of girls and 66·7 % of boys. 25(OH)D ≥ 50 nmol/l was significantly associated with higher whole-body BMD after adjusting for the influence of sex, height, fat mass and lean mass. A linear relationship between 25(OH)D and whole-body BMD was significant for 25(OH)D < 50 nmol/l (n 199, P < 0·05) but NS for 25(OH)D ≥ 50 nmol/l (n 86, P = 0·48).Conclusions: Our results are in line with some but not all previous studies on the relationship between BMD and 25(OH)D in adolescents. The observed difference in BMD between those with above v. below a 25(OH)D concentration of 50 nmol/l was of about a fifth of one SD, which may have a clinical relevance as one SD decrease in volumetric BMD has been associated with a 89 % increase in 2 years risk of fracture. Icelandic adolescents should be encouraged to increase their vitamin D intake as it is possible that their current intake is insufficient to achieve optimal peak bone mass.
dc.description.sponsorship The authors would like to thank the participants of the study, the staff at the Icelandic Heart Association. They also thank The Icelandic Centre for Research (RANNIS) and the Research Fund of the Icelandic College of Family Physicians for financial support. Financial support : The study was funded by the Icelandic Centre for research (RANNIS) (grant number 152509-051). Conflict of interest : The authors certify that they have NO affiliations with or involvement in any organisation or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. Authorship : S.L.G. and H.H. wrote the manuscript with input from all authors. H.H. and S.L.G. designed the statistical models and H.H. performed the data analyses. E.L.S. and E.J. conceived the study and managed the overall direction of the project. Disclosure: The Icelandic Centre for Research had no role in the design, analysis or writing of this article. Ethics of human subject participation : The current study was conducted according to the guidelines laid down in the Declaration of Helsinki, and all procedures involving research study participants were approved by The National Bioethics Committee in Iceland. Written informed consent was obtained from all subjects and their guardians.
dc.format.extent 1329-1333
dc.language.iso en
dc.publisher Cambridge University Press (CUP)
dc.relation.ispartofseries Public Health Nutrition;23(8)
dc.rights info:eu-repo/semantics/openAccess
dc.subject 25-hydroxyvitamin D
dc.subject Adolescent
dc.subject Bone mineral density
dc.subject Cross sectional
dc.subject Vitamin D
dc.subject Ungt fólk
dc.subject D vítamín
dc.subject Beinþéttni
dc.title Serum 25-hydroxyvitamin D concentrations in 16-year-old Icelandic adolescent and its association with bone mineral density
dc.type info:eu-repo/semantics/article
dcterms.license This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.description.version Peer Reviewed
dc.identifier.journal Public Health Nutrition
dc.identifier.doi 10.1017/S1368980019004142
dc.relation.url https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S1368980019004142
dc.contributor.department Deild heilsueflingar, íþrótta og tómstunda (HÍ)
dc.contributor.department Faculty of Health Promotion, Sport and Leisure Studies (UI)
dc.contributor.school Menntavísindasvið (HÍ)
dc.contributor.school School of Education (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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