dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Gudmundsdottir, Sigridur Lara |
dc.contributor.author |
Hrafnkelsson, Hrafn |
dc.contributor.author |
Sigurdsson, Engilbert |
dc.contributor.author |
Johannsson, Erlingur |
dc.date.accessioned |
2021-01-11T14:56:09Z |
dc.date.available |
2021-01-11T14:56:09Z |
dc.date.issued |
2020-03-19 |
dc.identifier.citation |
Gudmundsdottir, S., Hrafnkelsson, H., Sigurdsson, E., & Johannsson, E. (2020). Serum 25-hydroxyvitamin D concentrations in 16-year-old Icelandic adolescent and its association with bone mineral density. Public Health Nutrition, 23(8), 1329-1333. doi:10.1017/S1368980019004142 |
dc.identifier.issn |
1368-9800 |
dc.identifier.issn |
1475-2727 (eISSN) |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/2346 |
dc.description |
Publisher's version (útgefin grein) |
dc.description.abstract |
Objective: The aim of the study was to assess the potential association between serum 25-hydroxyvitamin D (25(OH)D) and whole-body bone mineral density (BMD) among 16-year-old adolescents and to study the prevalence of 25(OH)D insufficiency, defined as concentration under 50 nmol/l.Design: A cross-sectional study.Setting: Reykjavik, Iceland, latitude 64°08′N. Measurements took place in the Icelandic Heart Association's research lab during April-June 2015.Participants: In total, 411 students in Reykjavik, Iceland, were invited to participate, 315 accepted the invitation (76·6 %) and 289 had valid data (mainly Caucasian).Results: 25(OH)D < 50 nmol/l was observed in 70 % of girls and 66·7 % of boys. 25(OH)D ≥ 50 nmol/l was significantly associated with higher whole-body BMD after adjusting for the influence of sex, height, fat mass and lean mass. A linear relationship between 25(OH)D and whole-body BMD was significant for 25(OH)D < 50 nmol/l (n 199, P < 0·05) but NS for 25(OH)D ≥ 50 nmol/l (n 86, P = 0·48).Conclusions: Our results are in line with some but not all previous studies on the relationship between BMD and 25(OH)D in adolescents. The observed difference in BMD between those with above v. below a 25(OH)D concentration of 50 nmol/l was of about a fifth of one SD, which may have a clinical relevance as one SD decrease in volumetric BMD has been associated with a 89 % increase in 2 years risk of fracture. Icelandic adolescents should be encouraged to increase their vitamin D intake as it is possible that their current intake is insufficient to achieve optimal peak bone mass. |
dc.description.sponsorship |
The authors would like to thank the participants of the study, the staff at the Icelandic Heart Association. They also thank The Icelandic Centre for Research (RANNIS) and the Research Fund of the Icelandic College of Family Physicians for financial support. Financial support : The study was funded by the Icelandic Centre for research (RANNIS) (grant number 152509-051). Conflict of interest : The authors certify that they have NO affiliations with or involvement in any organisation or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. Authorship : S.L.G. and H.H. wrote the manuscript with input from all authors. H.H. and S.L.G. designed the statistical models and H.H. performed the data analyses. E.L.S. and E.J. conceived the study and managed the overall direction of the project. Disclosure: The Icelandic Centre for Research had no role in the design, analysis or writing of this article. Ethics of human subject participation : The current study was conducted according to the guidelines laid down in the Declaration of Helsinki, and all procedures involving research study participants were approved by The National Bioethics Committee in Iceland. Written informed consent was obtained from all subjects and their guardians. |
dc.format.extent |
1329-1333 |
dc.language.iso |
en |
dc.publisher |
Cambridge University Press (CUP) |
dc.relation.ispartofseries |
Public Health Nutrition;23(8) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
25-hydroxyvitamin D |
dc.subject |
Adolescent |
dc.subject |
Bone mineral density |
dc.subject |
Cross sectional |
dc.subject |
Vitamin D |
dc.subject |
Ungt fólk |
dc.subject |
D vítamín |
dc.subject |
Beinþéttni |
dc.title |
Serum 25-hydroxyvitamin D concentrations in 16-year-old Icelandic adolescent and its association with bone mineral density |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
Public Health Nutrition |
dc.identifier.doi |
10.1017/S1368980019004142 |
dc.relation.url |
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S1368980019004142 |
dc.contributor.department |
Deild heilsueflingar, íþrótta og tómstunda (HÍ) |
dc.contributor.department |
Faculty of Health Promotion, Sport and Leisure Studies (UI) |
dc.contributor.school |
Menntavísindasvið (HÍ) |
dc.contributor.school |
School of Education (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |