Opin vísindi

Antipsychotic drug use in pregnancy: A multinational study from ten countries

Antipsychotic drug use in pregnancy: A multinational study from ten countries

Title: Antipsychotic drug use in pregnancy: A multinational study from ten countries
Author: Reutfors, Johan   orcid.org/0000-0003-1372-4262
Cesta, Carolyn E.
Cohen, Jacqueline M.
Bateman, Brian T.
Brauer, Ruth
Einarsdóttir, Kristjana
Engeland, Anders
Furu, Kari
Gissler, Mika
Havard, Alys
... 13 more authors Show all authors
Date: 2020-06
Language: English
Scope: 106-115
University/Institute: Háskóli Íslands
University of Iceland
School: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Department: Læknadeild (HÍ)
Faculty of Medicine (UI)
Series: Schizophrenia Research;220
ISSN: 0920-9964
DOI: 10.1016/j.schres.2020.03.048
Subject: Antipsychotics; Drug utilization study; Epidemiology; Pharmacological treatment; Pregnancy; Geðlyf; Meðganga
URI: https://hdl.handle.net/20.500.11815/2345

Show full item record


Reutfors, J., Cesta, C., Cohen, J., Bateman, B., Brauer, R., Einarsdóttir, K., . . . Schaffer, A. (2020). Antipsychotic drug use in pregnancy: A multinational study from ten countries. Schizophrenia Research, 220, 106-115.


Aim: To compare the prevalence and trends of antipsychotic drug use during pregnancy between countries across four continents. Methods: Individually linked health data in Denmark (2000−2012), Finland (2005–2014), Iceland (2004–2017), Norway (2005–2015), Sweden (2006–2015), Germany (2006–2015), Australia (New South Wales, 2004–2012), Hong Kong (2001–2015), UK (2006–2016), and the US (Medicaid, 2000–2013, and IBM MarketScan, 2012–2015) were used. Using a uniformed approach, we estimated the prevalence of antipsychotic use as the proportion of pregnancies where a woman filled at least one antipsychotic prescription within three months before pregnancy until birth. For the Nordic countries, data were meta-analyzed to investigate maternal characteristics associated with the use of antipsychotics. Results: We included 8,394,343 pregnancies. Typical antipsychotic use was highest in the UK (4.4%) whereas atypical antipsychotic use was highest in the US Medicaid (1.5%). Atypical antipsychotic use increased over time in most populations, reaching 2% in Australia (2012) and US Medicaid (2013). In most countries, prochlorperazine was the most commonly used typical antipsychotic and quetiapine the most commonly used atypical antipsychotic. Use of antipsychotics decreased across the trimesters of pregnancy in all populations except Finland. Antipsychotic use was elevated among smokers and those with parity ≥4 in the Nordic countries. Conclusion: Antipsychotic use during pregnancy varied considerably between populations, partly explained by varying use of the typical antipsychotic prochlorperazine, which is often used for nausea and vomiting in early pregnancy. Increasing usage of atypical antipsychotics among pregnant women reflects the pattern that was previously reported for the general population.


Publisher's version (útgefin grein)


his is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Files in this item

This item appears in the following Collection(s)