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Low serum DHEA-S is associated with impaired lung function in women

Low serum DHEA-S is associated with impaired lung function in women

Title: Low serum DHEA-S is associated with impaired lung function in women
Author: Pesce, Giancarlo
Triebner, Kai
van der Plaat, Diana A.
Courbon, Dominique
Hustad, Steinar
Sigsgaard, Torben
Nowak, Dennis
Heinrich, Joachim
Anto, Josep M.
Dorado-Arenas, Sandra
... 19 more authors Show all authors
Date: 2020-06
Language: English
Scope: 100389
University/Institute: Háskóli Íslands
University of Iceland
School: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Department: Læknadeild (HÍ)
Faculty of Medicine (UI)
Series: EClinicalMedicine;23
ISSN: 2589-5370
DOI: 10.1016/j.eclinm.2020.100389
Subject: Airflow obstruction; Androgens; Cohort studies; Sex hormones; Karlhormónar; Kynhormónar; Öndunarfæri
URI: https://hdl.handle.net/20.500.11815/2341

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Pesce, G., Triebner, K., Van Der Plaat, D.A., Courbon, D., Hustad, S., Sigsgaard, T., Nowak, D., Heinrich, J., Anto, J.M., Dorado-Arenas, S., Martinez-Moratalla, J., Gullon-Blanco, J.A., Sanchez-Ramos, J.L., Raherison, C., Pin, I., Demoly, P., Gislason, T., Torén, K., Forsberg, B., Lindberg, E., Zemp, E., Jogi, R., Probst-Hensch, N., Dharmage, S.C., Jarvis, D., Garcia-Aymerich, J., Marcon, A., Gómez-Real, F., Leynaert, B., 2020. Low serum DHEA-S is associated with impaired lung function in women. EClinicalMedicine 23, 100389. doi:10.1016/j.eclinm.2020.100389


Background: Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS). Methods: Lung function and serum DHEA-S concentrations were measured in n = 2,045 and n = 1,725 women in 1999–2002 and in 2010–2013, respectively. Cross-sectional associations of DHEA-S levels (expressed as age-adjusted z-score) with spirometric outcomes were investigated, adjusting for smoking habits, body mass index, menopausal status, and use of corticosteroids. Longitudinal associations of DHEA-S levels in 1999–2002 with incidence of restrictive pattern and airflow limitation in 2010–2013 were also assessed. Findings: Women with low DHEA-S (z-score<-1) had lower FEV1 (% of predicted, adjusted difference: -2.2; 95%CI: -3.5 to -0.9) and FVC (-1.7; 95%CI: -2.9 to -0.5) and were at a greater risk of having airflow limitation and restrictive pattern on spirometry than women with higher DHEA-S levels. In longitudinal analyses, low DHEA-S at baseline was associated with a greater incidence of airflow limitation after an 11-years follow-up (incidence rate ratio, 3.43; 95%CI: 1.91 to 6.14). Interpretation: Low DHEA-S levels in women were associated with impaired lung function and a greater risk of developing airflow limitation later in adult life. Our findings provide new evidence supporting a role of DHEA-S in respiratory health.


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This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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