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Characterization and Evaluation of Ternary Complexes of Ascorbic Acid with γ-Cyclodextrin and Poly(vinyl Alcohol)

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Saokham, Phennapha
dc.contributor.author Burapapadh, Kanokporn
dc.contributor.author Praphanwittaya, Pitsiree
dc.contributor.author Loftsson, Thorsteinn
dc.date.accessioned 2021-01-11T10:42:15Z
dc.date.available 2021-01-11T10:42:15Z
dc.date.issued 2020-06-20
dc.identifier.citation Saokham, P.; Burapapadh, K.; Praphanwittaya, P.; Loftsson, T. Characterization and Evaluation of Ternary Complexes of Ascorbic Acid with γ-Cyclodextrin and Poly(vinyl Alcohol). International Journal of Molecular Sciences 2020, 21, 4399.
dc.identifier.issn 1422-0067
dc.identifier.uri https://hdl.handle.net/20.500.11815/2338
dc.description Publisher's version (útgefin grein)
dc.description.abstract Ascorbic acid (AA) is a general antioxidant used in aqueous pharmaceutical formulations. However, in aqueous solutions, AA is unstable and easily oxidized when exposed to air, light and/or heat. Cyclodextrins are well known for their ability to form inclusion complexes with various compounds to improve their solubility and stability. Previous studies demonstrate that cyclodextrins preserve the antioxidant capacity of AA but data for γ-cyclodextrin (γCD) have not been reported. Poly(vinyl alcohol) (PVA) is a hydrophilic polymer widely used as a drug matrix in various pharmaceutical fields, but its application for drug stabilization is limited. This study aimed to investigate the protective ability of γCD on AA through the formation of ternary complexes with PVA. Binary (i.e., AA/γCD, AA/PVA and γCD/PVA) and ternary (i.e., AA/γCD/PVA) complexes were first confirmed. It was reported that those complexes were formed through interactions between the heterocyclic ring of AA, hydroxyl group of PVA and hydrophobic cavity of γCD. The hydrodynamic diameter of complexes was then studied. It was found that the diameter of γCD/PVA complexes increased with respect to the concentration of γCD. Higher γCD concentrations also resulted in increasing hydrodynamic diameters of the ternary complex. The presence of AA in ternary complexes interfered with the aggregation tendency of γCD/PVA binary complexes. Furthermore, the antioxidant capacity of AA in binary and ternary complexes was investigated. It was found that the presence of γCD preserved the antioxidant activity of AA, whereas PVA showed a contrasting effect. The influence of γCD and PVA concentration on antioxidant capacity was then studied through central composite design (CCD). Even though the concentration of γCD significantly affected the inhibition efficiency of the ternary complex, the insignificant influence of PVA could not be ignored. A promising protective ternary complex should consist of an optimized concentration of PVA and a high concentration of γCD.
dc.description.sponsorship The authors would like to express their gratitude to sta?s at the Department of Manufacturing Pharmacy and Department of Pharmaceutical Technology ,College of Pharmacy, Rangsit University and Faculty of Pharmaceutical Sciences, University of Iceland.
dc.format.extent 4399
dc.language.iso en
dc.publisher MDPI AG
dc.relation.ispartofseries International Journal of Molecular Sciences;21(12)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Antioxidant activity
dc.subject Ascorbic acid
dc.subject Inclusion complex
dc.subject Poly(vinyl alcohol)
dc.subject γ-cyclodextrin
dc.subject Sýklódextrín
dc.subject Lyfjaefnafræði
dc.title Characterization and Evaluation of Ternary Complexes of Ascorbic Acid with γ-Cyclodextrin and Poly(vinyl Alcohol)
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.description.version Peer Reviewed
dc.identifier.journal International Journal of Molecular Sciences
dc.identifier.doi 10.3390/ijms21124399
dc.relation.url https://www.mdpi.com/1422-0067/21/12/4399/pdf
dc.contributor.department Lyfjafræðideild (HÍ)
dc.contributor.department Faculty of Pharmaceutical Sciences (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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