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Describing the status of reproductive ageing simply and precisely: A reproductive ageing score based on three questions and validated with hormone levels

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Triebner, Kai
dc.contributor.author Johannessen, Ane
dc.contributor.author Svanes, Cecilie
dc.contributor.author Leynaert, Bénédicte
dc.contributor.author Benediktsdóttir, Bryndís
dc.contributor.author Demoly, Pascal
dc.contributor.author Dharmage, Shyamali C.
dc.contributor.author Franklin, Karl A.
dc.contributor.author Heinrich, Joachim
dc.contributor.author Holm, Mathias
dc.contributor.author Jarvis, Deborah
dc.contributor.author Lindberg, Eva
dc.contributor.author Rovira, Jesús Martínez Moratalla
dc.contributor.author Muniozguren Agirre, Nerea
dc.contributor.author Sánchez-Ramos, José Luis
dc.contributor.author Schlünssen, Vivi
dc.contributor.author Skulstad, Svein Magne
dc.contributor.author Hustad, Steinar
dc.contributor.author Rodriguez, Francisco J.
dc.contributor.author Gómez Real, Francisco
dc.date.accessioned 2021-01-11T10:31:05Z
dc.date.available 2021-01-11T10:31:05Z
dc.date.issued 2020-06-30
dc.identifier.citation Triebner K, Johannessen A, Svanes C,Leynaert B, Benediktsdottir B, Demoly P, et al.(2020)Describingthe statusof reproductiveageingsimplyand precisely:A reproductiveageingscorebasedon threequestionsand validatedwithhormonelevels.PLoSONE 15(6):e0235478.doi:10.1371/journal.pone.0235478
dc.identifier.issn 1932-6203
dc.identifier.uri https://hdl.handle.net/20.500.11815/2336
dc.description Publisher's version (útgefin grein)
dc.description.abstract Objective: Most women live to experience menopause and will spend 4–8 years transitioning from fertile age to full menstrual stop. Biologically, reproductive ageing is a continuous process, but by convention, it is defined categorically as pre-, peri- and postmenopause; categories that are sometimes supported by measurements of sex hormones in blood samples. We aimed to develop and validate a new tool, a reproductive ageing score (RAS), that could give a simple and yet precise description of the status of reproductive ageing, without hormone measurements, to be used by health professionals and researchers. Methods: Questionnaire data on age, menstrual regularity and menstrual frequency was provided by the large multicentre population-based RHINE cohort. A continuous reproductive ageing score was developed from these variables, using techniques of fuzzy mathematics, to generate a decimal number ranging from 0.00 (nonmenopausal) to 1.00 (postmenopausal). The RAS was then validated with sex hormone measurements (follicle stimulating hormone and 17β-estradiol) and interview-data provided by the large population-based ECRHS cohort, using receiver-operating characteristics (ROC). Results: The RAS, developed from questionnaire data of the RHINE cohort, defined with high precision and accuracy the menopausal status as confirmed by interview and hormone data in the ECRHS cohort. The area under the ROC curve was 0.91 (95% Confidence interval (CI): 0.90–0.93) to distinguish nonmenopausal women from peri- and postmenopausal women, and 0.85 (95% CI: 0.83–0.88) to distinguish postmenopausal women from nonmenopausal and perimenopausal women. Conclusions: The RAS provides a useful and valid tool for describing the status of reproductive ageing accurately, on a continuous scale from 0.00 to 1.00, based on simple questions and without requiring blood sampling. The score allows for a more precise differentiation than the conventional categorisation in pre-, peri- and postmenopause. This is useful for epidemiological research and clinical trials.
dc.description.sponsorship We thank all participants, field workers and coordinators of the RHINE study and the ECRHS for their efforts as well as Ersilia Bifulco and Sandra Suske from the Core Facility for Metabolomics at the University of Bergen where the hormone measurements were performed. Further we are very grateful for the support of the Department of Applied Mathematics of the University of Málaga (Spain) and we want to thank Elinor Bartle for revising grammar and language.
dc.format.extent e0235478
dc.language.iso en
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartofseries PLOS ONE;15(6)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Aging
dc.subject Follicle Stimulating Hormone
dc.subject Menopause
dc.subject Tíðahvörf
dc.title Describing the status of reproductive ageing simply and precisely: A reproductive ageing score based on three questions and validated with hormone levels
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article distributed under the terms of the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.description.version Peer Reviewed
dc.identifier.journal Plos One
dc.identifier.doi 10.1371/journal.pone.0235478
dc.relation.url https://dx.plos.org/10.1371/journal.pone.0235478
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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