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Parents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Knudsen, Gerd Toril Mørkve
dc.contributor.author Dharmage, Shyamali
dc.contributor.author Janson, Christer
dc.contributor.author Abramson, Michael J.
dc.contributor.author Benediktsdóttir, Bryndís
dc.contributor.author Malinovschi, Andrei
dc.contributor.author Skulstad, Svein Magne
dc.contributor.author Bertelsen, Randi Jacobsen
dc.contributor.author Real, Francisco Gomez
dc.contributor.author Schlünssen, Vivi
dc.contributor.author Jõgi, Nils Oskar
dc.contributor.author Sánchez-Ramos, José Luis
dc.contributor.author Holm, Mathias
dc.contributor.author Garcia-Aymerich, Judith
dc.contributor.author Forsberg, Bertil
dc.contributor.author Svanes, Cecilie
dc.contributor.author Johannessen, Ane
dc.date.accessioned 2020-12-18T12:05:09Z
dc.date.available 2020-12-18T12:05:09Z
dc.date.issued 2020-07-06
dc.identifier.citation Knudsen GTM, Dharmage S, Janson C, Abramson MJ, Benediktsdóttir B, Malinovschi A, et al. (2020) Parents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study. PLoS ONE 15(7): e0235632. https://doi.org/10.1371/journal.pone.0235632
dc.identifier.issn 1932-6203
dc.identifier.uri https://hdl.handle.net/20.500.11815/2305
dc.description Publisher's version (útgefin grein)
dc.description.abstract Emerging evidence suggests that parents’ preconception exposures may influence offspring health. We aimed to investigate maternal and paternal smoking onset in specific time windows in relation to offspring body mass index (BMI) and fat mass index (FMI). We investigated fathers (n = 2111) and mothers (n = 2569) aged 39–65 years, of the population based RHINE and ECRHS studies, and their offspring aged 18–49 years (n = 6487, mean age 29.6 years) who participated in the RHINESSA study. BMI was calculated from self-reported height and weight, and FMI was estimated from bioelectrical impedance measures in a subsample. Associations with parental smoking were analysed with generalized linear regression adjusting for parental education and clustering by study centre and family. Interactions between offspring sex were analysed, as was mediation by parental pack years, parental BMI, offspring smoking and offspring birthweight. Fathers’ smoking onset before conception of the offspring (onset ≥15 years) was associated with higher BMI in the offspring when adult (β 0.551, 95%CI: 0.174–0.929, p = 0.004). Mothers’ preconception and postnatal smoking onset was associated with higher offspring BMI (onset <15 years: β1.161, 95%CI 0.378–1.944; onset ≥15 years: β0.720, 95%CI 0.293–1.147; onset after offspring birth: β2.257, 95%CI 1.220–3.294). However, mediation analysis indicated that these effects were fully mediated by parents’ postnatal pack years, and partially mediated by parents’ BMI and offspring smoking. Regarding FMI, sons of smoking fathers also had higher fat mass (onset <15 years β1.604, 95%CI 0.269–2.939; onset ≥15 years β2.590, 95%CI 0.544–4.636; and onset after birth β2.736, 95%CI 0.621–4.851). There was no association between maternal smoking and offspring fat mass. We found that parents’ smoking before conception was associated with higher BMI in offspring when they reached adulthood, but that these effects were mediated through parents’ pack years, suggesting that cumulative smoking exposure during offspring’s childhood may elicit long lasting effects on offspring BMI.
dc.description.sponsorship Co-ordination of the RHINESSA study has received funding from the Research Council of Norway (Grants No. 274767, 214123, 228174, 230827 and 273838), ERC StG project BRuSH #804199, the European Union's Horizon 2020 research and innovation program under grant agreement No. 633212 (the ALEC Study WP2), the Bergen Medical Research Foundation, and the Western Norwegian Regional Health Authorities (Grants No. 912011, 911892 and 911631). Study centres have further received local funding from the following: Bergen: the above grants for study establishment and co-ordination, and, in addition, World University Network (RDF and Sustainability grant), Norwegian Labour Inspection, and the Norwegian Asthma and Allergy Association. Albacete and Huelva: SEPAR. Fondo de Investigación Sanitaria (FIS PS09). Gøteborg, Umeå and Uppsala: the Swedish Lung Foundation, the Swedish Asthma and Allergy Association. Reykjavik: Iceland University. Melbourne: NHMRC, Melbourne University, Tartu: the Estonian Research Council (Grant No. PUT562). Århus: The Danish Wood Foundation (Grant No. 444508795), the Danish Working Environment Authority (Grant No. 20150067134). The RHINE study received funding by Norwegian Research Council, Norwegian Asthma and Allergy Association, Danish Lung Association, Swedish Heart and Lung Foundation, Vårdal Foundation for Health Care Science and Allergy Research, Swedish Asthma and Allergy Association, Swedish Lung Foundation, Icelandic Research Council, and Estonian Science Foundation. The co-ordination of ECRHS was supported by European Union's Horizon 2020 research and innovation program under grant agreement No. 633212 (the ALEC Study), the European Commission frameworks 5 and 7 (ECRHS I and II) and the Medical Research Council (ECRHS III).
dc.format.extent e0235632
dc.language.iso en
dc.publisher Public Library of Science (PLoS)
dc.relation info:eu-repo/grantAgreement/EC/H2020/633212
dc.relation.ispartofseries Plos One;15(7)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Cotinine
dc.subject Childhood Obesity
dc.subject Smoking
dc.subject Reykingar
dc.subject Offita
dc.subject Börn
dc.title Parents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.description.version Peer Reviewed
dc.identifier.journal Plos One
dc.identifier.doi 10.1371/journal.pone.0235632
dc.relation.url https://dx.plos.org/10.1371/journal.pone.0235632
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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