dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Yanes, Manar |
dc.contributor.author |
Santoni, Giola |
dc.contributor.author |
Maret-Ouda, John |
dc.contributor.author |
Ness-Jensen, Eivind |
dc.contributor.author |
Färkkilä, Martti |
dc.contributor.author |
Lynge, Elsebeth |
dc.contributor.author |
Nwaru, Bright |
dc.contributor.author |
Pukkala, Eero |
dc.contributor.author |
Romundstad, Pål |
dc.contributor.author |
Tryggvadottir, Laufey |
dc.contributor.author |
von Euler-Chelpin, My |
dc.contributor.author |
Lagergren, Jesper |
dc.date.accessioned |
2020-11-09T13:43:52Z |
dc.date.available |
2020-11-09T13:43:52Z |
dc.date.issued |
2020-10 |
dc.identifier.citation |
Yanes, M., Santoni, G., Maret-Ouda, J., Ness-Jensen, E., Färkkilä, M., Lynge, E., . . . Lagergren, J. (2020). Antireflux surgery and risk of lung cancer by histological type in a multinational cohort study. European Journal of Cancer (1990), 138, 80-88. |
dc.identifier.issn |
0959-8049 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/2186 |
dc.description |
Publisher's version (útgefin grein) |
dc.description.abstract |
Introduction: Airway micro-aspiration might contribute to the proposed associations between gastroesophageal reflux disease (GERD) and some lung diseases, including lung cancer. This study aimed to examine the hypothesis that antireflux surgery decreases the risk of small cell carcinoma, squamous cell carcinoma and adenocarcinoma of the lung differently depending on their location in relation to micro-aspiration. Methods: Population-based cohort study including patients having undergone antireflux surgery during 1980–2014 in Denmark, Finland, Iceland, Norway or Sweden. Patients having undergone antireflux surgery were compared with two groups: 1) the corresponding background population, by calculating standardised incidence ratios (SIRs) with 95% confidence intervals (CIs) and 2) non-operated GERD-patients, by calculating hazard ratios (HRs) with 95% CIs using multivariable Cox regression with adjustment for sex, age, calendar period, country, chronic obstructive pulmonary disease and obesity diagnosis or type 2 diabetes. Results: Among all 812,617 GERD-patients, 46,996 (5.8%) had undergone antireflux surgery. The SIRs were statistically significantly decreased for small cell carcinoma (SIR = 0.57, 95% CI 0.41–0.77) and squamous cell carcinoma (SIR = 0.75, 95% CI 0.60–0.92), but not for adenocarcinoma of the lung (SIR = 0.90, 95% CI 0.76–1.06). The HRs were also below unity for small cell carcinoma (HR = 0.63, 95% CI 0.44–0.90) and squamous cell carcinoma (HR = 0.80, 95% CI 0.62–1.03), but not for adenocarcinoma of the lung (HR = 1.03, 95% CI 0.84–1.26). Analyses restricted to patients with objective GERD (reflux oesophagitis or Barrett's oesophagus) showed similar results. Conclusions: This all-Nordic study indicates that patients who undergo antireflux surgery are at decreased risk of small cell carcinoma and squamous cell carcinoma of the lung, but not of adenocarcinoma of the lung. |
dc.description.sponsorship |
This work was supported by the Nordic Cancer
Union (grant number 186058), Swedish Cancer Society
(grant number 180684), and Swedish Research Council
(grant number 340-2013-5478). Jesper Lagergren was
supported by the United European Gastroenterology
Research Prize and the Distinguished Professor Award
at Karolinska Institutet. |
dc.format.extent |
80-88 |
dc.language.iso |
en |
dc.publisher |
Elsevier BV |
dc.relation.ispartofseries |
European Journal of Cancer;138 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Cancer Research |
dc.subject |
Oncology |
dc.subject |
Bronchus |
dc.subject |
Fundoplication |
dc.subject |
GERD |
dc.subject |
GORD |
dc.subject |
Neoplasm |
dc.subject |
Nissen |
dc.subject |
Pulmonary |
dc.subject |
Krabbameinsrannsóknir |
dc.subject |
Krabbameinslækningar |
dc.subject |
Skurðlækningar |
dc.subject |
Lungnasjúkdómar |
dc.title |
Antireflux surgery and risk of lung cancer by histological type in a multinational cohort study |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This is an open access article under the CC BY license (http://creativecommons.org/
licenses/by/4.0/). |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
European Journal of Cancer |
dc.identifier.doi |
10.1016/j.ejca.2020.07.018 |
dc.relation.url |
https://www.sciencedirect.com/science/article/pii/S0959804920304135?via%3Dihub |
dc.contributor.department |
Læknadeild (HÍ) |
dc.contributor.department |
Faculty of Medicine (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |