dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Lorenzo Veiga, Blanca |
dc.contributor.author |
Diaz-Rodriguez, Patricia |
dc.contributor.author |
Alvarez-Lorenzo, Carmen |
dc.contributor.author |
Loftsson, Thorsteinn |
dc.contributor.author |
Sigurdsson, Hakon Hrafn |
dc.date.accessioned |
2020-10-29T12:18:44Z |
dc.date.available |
2020-10-29T12:18:44Z |
dc.date.issued |
2020-04-09 |
dc.identifier.citation |
Lorenzo-Veiga, B.; Diaz-Rodriguez, P.; Alvarez-Lorenzo, C.; Loftsson, T.; Sigurdsson, H.H. In Vitro and Ex Vivo Evaluation of Nepafenac-Based Cyclodextrin Microparticles for Treatment of Eye Inflammation. Nanomaterials 2020, 10, 709. doi:10.3390/nano10040709 |
dc.identifier.issn |
2079-4991 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/2147 |
dc.description |
Publisher's version (útgefin grein) |
dc.description.abstract |
The aim of this study was to design and evaluate novel cyclodextrin (CD)-based aggregate formulations to efficiently deliver nepafenac topically to the eye structure, to treat inflammation and increase nepafenac levels in the posterior segment, thus attenuating the response of inflammatory mediators. The physicochemical properties of nine aggregate formulations containing nepafenac/γ-CD/hydroxypropyl-β (HPβ)-CD complexes as well as their rheological properties, mucoadhesion, ocular irritancy, corneal and scleral permeability, and anti-inflammatory activity were investigated in detail. The results were compared with a commercially available nepafenac suspension, Nevanac® 3 mg/mL. All formulations showed microparticles, neutral pH, and negative zeta potential (–6 to –27 mV). They were non-irritating and nontoxic and showed high permeation through bovine sclera. Formulations containing carboxymethyl cellulose (CMC) showed greater anti-inflammatory activity, even higher than the commercial formulation, Nevanac® 0.3%. The optimized formulations represent an opportunity for topical instillation of drugs to the posterior segment of the eye. |
dc.description.sponsorship |
This research was funded by MINECO (SAF2017-83118-R), Agencia Estatal de Investigación (AEI)
Spain, Xunta de Galicia (ED431C 2016/008), and FEDER (Spain). B.L.-V. acknowledges an Erasmus+ traineeship
(IS-SM2018-81075). |
dc.format.extent |
709 |
dc.language.iso |
en |
dc.publisher |
MDPI AG |
dc.relation.ispartofseries |
Nanomaterials;10(4) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Eye drop |
dc.subject |
Cyclodextrin |
dc.subject |
Nepafenac |
dc.subject |
HET-CAM |
dc.subject |
Ex vivo permeation studies |
dc.subject |
Ocular inflammation |
dc.subject |
Augndropar |
dc.subject |
Sýklódextrín |
dc.subject |
Lyfhrifafræði |
dc.title |
In Vitro and Ex Vivo Evaluation of Nepafenac-Based Cyclodextrin Microparticles for Treatment of Eye Inflammation |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
Nanomaterials |
dc.identifier.doi |
10.3390/nano10040709 |
dc.relation.url |
https://www.mdpi.com/2079-4991/10/4/709/pdf |
dc.contributor.department |
Lyfjafræðideild (HÍ) |
dc.contributor.department |
Faculty of Pharmaceutical Sciences (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |