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Aspirin causes endothelium-dependent vasodilation of resistance arteries from non-gravid and gravid rats

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Helgadottir, Helga
dc.contributor.author Tropea, Teresa
dc.contributor.author Gizurarson, Sveinbjorn
dc.contributor.author Meiri, Hamutal
dc.contributor.author Mandalà, Maurizio
dc.date.accessioned 2020-10-13T14:36:27Z
dc.date.available 2020-10-13T14:36:27Z
dc.date.issued 2019-01
dc.identifier.citation Helgadottir, H., et al. (2019). "Aspirin causes endothelium-dependent vasodilation of resistance arteries from non-gravid and gravid rats." Pregnancy Hypertension 15: 141-145.
dc.identifier.issn 2210-7789
dc.identifier.uri https://hdl.handle.net/20.500.11815/2116
dc.description Publisher's version (útgefin grein)
dc.description.abstract Objective:Theobjectiveofthisstudywastounderstandtheeffectofacetylsalicylicacid(aspirin)onresistancearteriesfrommesenteryanduterus.Duringpregnancy,the uterine vasculature undergoes consistent growth to provide sufficient uteroplacental blood flow, a process whose failure is associated with pregnancy compli-cations characterized by high uterine vascular resistance.Methods:Uterine arcuate (UA) and mesenteric arteries (MA; diameter<300μm) isolated from non-gravid, mid-gravid (day 14), and late-gravid rats (day 20) wereexposedtoaspirin(10−12to10−5M).Further,inUAfromlate-gravidrats,aspirinwasevaluatedinpresenceofinhibitorsofnitricoxidesynthases,cyclooxygenase,cyclic nucleotides (cAMP, cGMP) and BK channels, and also on endothelium-denuded vessels.Results:Aspirin dilated both UA and MA in a dose dependent manner. Pregnancy increased aspirin vasodilation in MA and UA from mid-gravid rats, an effect thatwas reduced in vessels from late gravid animals at concentrations>10−7M. Further, uterine vasodilation was significantly reduced when the endothelium wasremoved (p < 0.001), and by inhibitors of nitric oxide synthase (p < 0.001), cyclooxygenase synthase (p < 0.05), cyclic nucleotides cGMP/cAMP and BKchannels.Conclusion:This is the first study to show a direct vasodilatory effect of aspirin on rat uterine artery that is mediated by a combination of cellular – primarilyendothelial - mechanisms. Our results in UA suggest that the use of aspirin may be effective in enhancing uteroplacental blood flow,while its vasodilation effect onMA may lower peripheral resistance.
dc.description.sponsorship This study was supported by grants from the European Union 7th Framework Programme – FP7-HEALTH-2013-INNOVATION-2 (ASPRE Project # 601852), Hananja ehf, and by the Icelandic Research Fund.
dc.format.extent 141-145
dc.language.iso en
dc.publisher Elsevier BV
dc.relation info:eu-repo/grantAgreement/EC/FP7/601852
dc.relation.ispartofseries Pregnancy Hypertension;15
dc.rights info:eu-repo/semantics/openAccess
dc.subject Aspirin
dc.subject Endothelium-dependent
dc.subject Mesentery
dc.subject Uterus
dc.subject Verkjalyf
dc.subject Meðganga
dc.subject Leg
dc.title Aspirin causes endothelium-dependent vasodilation of resistance arteries from non-gravid and gravid rats
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
dc.description.version Peer Reviewed
dc.identifier.journal Pregnancy Hypertension
dc.identifier.doi 10.1016/j.preghy.2019.01.001
dc.relation.url https://www.sciencedirect.com/science/article/pii/S2210778918300370
dc.contributor.department Lyfjafræðideild (HÍ)
dc.contributor.department Faculty of Pharmaceutical Sciences (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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