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Exercise Training Adds Cardiometabolic Benefits of a Paleolithic Diet in Type 2 Diabetes Mellitus

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Otten, Julia
dc.contributor.author Andersson, Jonas
dc.contributor.author Ståhl, Jens
dc.contributor.author Stomby, Andreas
dc.contributor.author Saleh, Ahmed
dc.contributor.author Waling, Maria
dc.contributor.author Ryberg, Mats
dc.contributor.author Hauksson, Jon
dc.contributor.author Svensson, Michael
dc.contributor.author Johansson, Bengt
dc.contributor.author Olsson, Tommy
dc.date.accessioned 2020-10-13T14:31:16Z
dc.date.available 2020-10-13T14:31:16Z
dc.date.issued 2019-01-22
dc.identifier.citation Otten, J., et al. (2019). "Exercise Training Adds Cardiometabolic Benefits of a Paleolithic Diet in Type 2 Diabetes Mellitus." Journal of the American Heart Association 8(2): e010634.
dc.identifier.issn 2047-9980
dc.identifier.uri https://hdl.handle.net/20.500.11815/2115
dc.description Publisher's version (útgefin grein)
dc.description.abstract Background The accumulation of myocardial triglycerides and remodeling of the left ventricle are common features in type 2 diabetes mellitus and represent potential risk factors for the development of diastolic and systolic dysfunction. A few studies have investigated the separate effects of diet and exercise training on cardiac function, but none have investigated myocardial changes in response to a combined diet and exercise intervention. This 12-week randomized study assessed the effects of a Paleolithic diet, with and without additional supervised exercise training, on cardiac fat, structure, and function. Methods and Results Twenty-two overweight and obese subjects with type 2 diabetes mellitus were randomized to either a Paleolithic diet and standard-care exercise recommendations (PD) or to a Paleolithic diet plus supervised exercise training 3 hours per week (PD-EX). This study includes secondary end points related to cardiac structure and function, ie, myocardial triglycerides levels, cardiac morphology, and strain were measured using cardiovascular magnetic resonance, including proton spectroscopy, at baseline and after 12 weeks. Both groups showed major favorable metabolic changes. The PD-EX group showed significant decreases in myocardial triglycerides levels (−45%, P=0.038) and left ventricle mass to end-diastolic volume ratio (−13%, P=0.008) while the left ventricle end-diastolic volume and stroke volume increased significantly (+14%, P=0.004 and +17%, P=0.008, respectively). These variables were unchanged in the PD group. Conclusions Exercise training plus a Paleolithic diet reduced myocardial triglycerides levels and improved left ventricle remodeling in overweight/obese subjects with type 2 diabetes mellitus.
dc.description.sponsorship This work was supported by grants from the Swedish Heart and Lung Foundation (20120450); King Gustav V and Queen Victoria's Foundation; The Swedish Diabetes Research Foundation (2014‐096); the County Council of Västerbotten (VLL‐460481); and Umeå University, Sweden.
dc.format.extent e010634
dc.language.iso en
dc.publisher Ovid Technologies (Wolters Kluwer Health)
dc.relation.ispartofseries Journal of the American Heart Association;8(2)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Cardiovascular magnetic resonance imaging
dc.subject Diet
dc.subject Exercise
dc.subject Myocardial metabolism
dc.subject Type 2 diabetes mellitus
dc.subject Blóðrásarsjúkdómar
dc.subject Segulómun
dc.subject Sykursýki
dc.subject Hreyfing (heilsurækt)
dc.title Exercise Training Adds Cardiometabolic Benefits of a Paleolithic Diet in Type 2 Diabetes Mellitus
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
dc.description.version Peer Reviewed
dc.identifier.journal Journal of the American Heart Association
dc.identifier.doi 10.1161/JAHA.118.010634
dc.relation.url https://www.ahajournals.org/doi/10.1161/JAHA.118.010634
dc.contributor.department Læknadeild (HÍ)
dc.contributor.department Faculty of Medicine (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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