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Distinct Profiles on Subjective and Objective Adherence Measures in Patients Prescribed Antidepressants

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Wouters, Hans
dc.contributor.author Rhebergen, Didi
dc.contributor.author Vervloet, Marcia
dc.contributor.author Egberts, Antoine
dc.contributor.author Taxis, Katja
dc.contributor.author van Dijk, Liset
dc.contributor.author Gardarsdottir, Helga
dc.date.accessioned 2020-10-08T11:36:43Z
dc.date.available 2020-10-08T11:36:43Z
dc.date.issued 2019-04-03
dc.identifier.citation Wouters, H., Rhebergen, D., Vervloet, M. et al. Distinct Profiles on Subjective and Objective Adherence Measures in Patients Prescribed Antidepressants. Drugs 79, 647–654 (2019). https://doi.org/10.1007/s40265-019-01107-y
dc.identifier.issn 0012-6667
dc.identifier.issn 1179-1950 (eISSN)
dc.identifier.uri https://hdl.handle.net/20.500.11815/2101
dc.description Publisher's version (útgefin grein)
dc.description.abstract Objective: A recurrent observation is that associations between self-reported and objective medication adherence measures are often weak to moderate. Our aim was therefore to identify patients with different profiles on self-reported and objective adherence measures. Study Design and Setting: This was an observational study of 221 community pharmacy patients who were dispensed antidepressants. Adherence profiles were estimated with Latent Profile Analysis (LPA) using data on self-reported adherence (Medication Adherence Rating Scale) complemented with data on medication beliefs (perceived necessity and concerns measured with the Beliefs about Medicines Questionnaire) and data from objective adherence measures (electronic monitoring of medication taking and the Medication Possession Ratio calculated from pharmacy dispensing data). Results: ‘Goodness-of-fit’ statistics indicated the presence of three classes: “concordantly high adherent” (83%, high adherence on all measures), “concordantly suboptimal adherent” (11%, low adherence on all measures), and “discordant” (6%, high self-reported adherence but lower adherence on objective measures). Conclusion: Most patients had concordant outcomes on self-reported and objective measures of adherence. A small discordant class had high self-reported but low objective adherence. LPA will enable sensitivity analyses in future studies, for example excluding patients from the discordant class.
dc.description.sponsorship The study was financially supported by a VENI grant from the Netherlands Organization for Health Research and Development (ZonMw) awarded to HG (Grant Number 91611147). LvD reports funding for studies not related to this manuscript from Astra Zeneca, Pfizer, and AbbVie.
dc.format.extent 647-654
dc.language.iso en
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartofseries Drugs;79(6)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Objective Adherence Measures
dc.subject Antidepressants
dc.subject Sjúklingar
dc.subject Geðlyf
dc.subject Þunglyndislyf
dc.title Distinct Profiles on Subjective and Objective Adherence Measures in Patients Prescribed Antidepressants
dc.type info:eu-repo/semantics/article
dcterms.license Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
dc.description.version Peer Reviewed
dc.identifier.journal Drugs
dc.identifier.doi 10.1007/s40265-019-01107-y
dc.relation.url https://link.springer.com/article/10.1007/s40265-019-01107-y
dc.contributor.department Lyfjafræðideild (HÍ)
dc.contributor.department Faculty of Pharmaceutical Sciences (UI)
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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