dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Chakraborty, Sandeep |
dc.contributor.author |
Ásgeirsson, Bjarni |
dc.contributor.author |
Dutta, Mouparna |
dc.contributor.author |
Ghosh, Anindya S. |
dc.contributor.author |
Oda, Masataka |
dc.contributor.author |
Rendón, Adela |
dc.contributor.author |
Goñi, Felix |
dc.contributor.author |
Frere, Jean-Marie |
dc.contributor.author |
Venkatramani, Ravindra |
dc.contributor.author |
Dandekar, Abhaya M. |
dc.contributor.author |
Rao, Basuthkar J. |
dc.date.accessioned |
2020-08-25T10:39:38Z |
dc.date.available |
2020-08-25T10:39:38Z |
dc.date.issued |
2014-01-20 |
dc.identifier.citation |
Chakraborty S, Asgeirsson B, Dutta M et al. Promiscuous scaffolds in proteins - non-native, non-additive and non-trivial [version 2; peer review: 1 approved with reservations, 2 not approved]. F1000Research 2014, 2:260 (https://doi.org/10.12688/f1000research.2-260.v2) |
dc.identifier.issn |
2046-1402 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/2016 |
dc.description |
Publisher's version (útgefin grein) |
dc.description.abstract |
Promiscuity, the ability of an enzyme to catalyze diverse activities using the same active site, sets up the stage for the evolution of complex organisms through gene duplication and specialization. The detection of promiscuous motifs is crucial to understand the physiological relevance of a protein, or for any endeavor that intends to rationally modify these latent capabilities to design new proteins under laboratory conditions. We have established a methodology for identifying catalytic residues based on spatial and electrostatic congruence with known active site configurations. Here, we discuss insights gained in several initiatives using our method on different enzymes. |
dc.description.sponsorship |
Icelandic reasearch fund (RANNÍS) No. 141619 |
dc.language.iso |
en |
dc.publisher |
F1000Research |
dc.relation.ispartofseries |
F1000Research;2(260) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.title |
Promiscuous scaffolds in proteins - non-native, non-additive and non-trivial |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
© 2014 Chakraborty S et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
dc.description.version |
Peer reviewed |
dc.identifier.journal |
F1000Research |
dc.identifier.doi |
10.12688/f1000research.2-260.v2 |
dc.relation.url |
https://f1000research.com/articles/2-260 |
dc.contributor.department |
Raunvísindadeild (HÍ) |
dc.contributor.department |
Faculty of Physical Sciences (UI) |
dc.contributor.department |
Raunvísindastofnun (HÍ) |
dc.contributor.department |
Science Institute (UI) |
dc.contributor.school |
Verkfræði- og náttúruvísindasvið (HÍ) |
dc.contributor.school |
School of Engineering and Natural Sciences (UI) |