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Hyperuricemia is associated with intermittent hand joint pain in a cross sectional study of elderly females: The AGES-Reykjavik Study

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dc.contributor Háskóli Íslands
dc.contributor University of Iceland
dc.contributor.author Jonsson, Helgi
dc.contributor.author Aspelund, Thor
dc.contributor.author Eiriksdottir, Gudny
dc.contributor.author Harris, Tamara B.
dc.contributor.author Launer, Lenore J.
dc.contributor.author Gudnason, Vilmundur
dc.date.accessioned 2020-08-13T11:07:01Z
dc.date.available 2020-08-13T11:07:01Z
dc.date.issued 2019-08-23
dc.identifier.citation Jonsson H, Aspelund T, Eiriksdottir G, Harris TB, Launer LJ, Gudnason V (2019) Hyperuricemia is associated with intermittent hand joint pain in a cross sectional study of elderly females: The AGES-Reykjavik Study. PLoS ONE 14(8): e0221474. https://doi.org/10.1371/journal.pone.0221474
dc.identifier.issn 1932-6203
dc.identifier.uri https://hdl.handle.net/20.500.11815/1985
dc.description Publisher's version (útgefin grein)
dc.description.abstract Background: The debate whether "asymptomatic hyperuricemia" should be treated is still ongoing. The objective of this cross-sectional study was to analyze whether hyperuricema in the elderly is associated with joint pain. Methods and findings: Participants in the population-based AGES-Reykjavik Study (males 2195, females 2975, mean age 76(6)) answered standardized questions about joint pain. In addition they recorded intermittent hand joint pain by marking a diagram of the hand. In males, no association was found between hyperuricemia and pain. Females however, showed a positive association between hyperuricemia and joint pain at many sites. After adjustment for age, BMI and hand osteoarthritis however, only intermittent hand joint pain (OR 1.30(1.07-1.58), p = 0.008) and intermittent pain in ≥10 hand joints (OR 1.75(1.32-2.31), p<0.001) remained significant. The best model for describing the relationship between serum uric acid levels (SUA) and intermittent hand joint pain in ≥10 joints was non-linear with a cut-off at 372 μmol/L. The attributable surplus number of symptomatic females with SUA ≥372 μmol/L was approximately 2.0% of the study population for those reporting pain in ≥10 hand joints. Next after having severe hand osteoarthritis, SUA ≥372 was an independent predictive factor of intermittent pain in ≥10 hand joints. Intermittent hand joint pain was also an independent risk factor for worse general health description. Conclusion: Results from this population based study indicate that hyperuricemia in elderly females may be a rather frequent cause of intermittent hand joint pain, often in many joints. The most likely explanation relates to low-grade urate crystal induced inflammation. Our data do not allow for assessment of the severity of symptoms or whether they merit specific treatment, but intermittent hand joint pain was an independent predictor of worse general health. These findings may be an important contribution to the debate on whether hyperuricemia should be treated.
dc.description.sponsorship Age, Gene/Environment Susceptibility Reykjavik Study (AGES-Reykjavik) has been funded by NIH contract N01-AG-12100 to TBH, the NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association), and the Althingi (the Icelandic Parliament), the Icelandic Osteoarthritis Fund and the University of Iceland Research Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.format.extent e0221474
dc.language.iso en
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartofseries Plos One;14(8)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Asymptomatic hyperuricemia
dc.subject Elderly
dc.subject Joint pain
dc.subject Aldraðir
dc.subject Liðamót
dc.subject Verkir
dc.subject Blóðrásarsjúkdómar
dc.title Hyperuricemia is associated with intermittent hand joint pain in a cross sectional study of elderly females: The AGES-Reykjavik Study
dc.type info:eu-repo/semantics/article
dcterms.license This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
dc.description.version Peer Reviewed
dc.identifier.journal Plos One
dc.identifier.doi 10.1371/journal.pone.0221474
dc.relation.url http://dx.plos.org/10.1371/journal.pone.0221474
dc.contributor.school Heilbrigðisvísindasvið (HÍ)
dc.contributor.school School of Health Sciences (UI)

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