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Site-directed spin labeling of 2′-amino groups in RNA with isoindoline nitroxides that are resistant to reduction
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| Titill: | Site-directed spin labeling of 2′-amino groups in RNA with isoindoline nitroxides that are resistant to reduction |
| Höfundur: |
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| Útgáfa: | 2015 |
| Tungumál: | Enska |
| Umfang: | 13142-13145 |
| Háskóli/Stofnun: | Háskóli Íslands University of Iceland |
| Svið: | Verkfræði- og náttúruvísindasvið (HÍ) School of Engineering and Natural Sciences (UI) |
| Deild: | Raunvísindadeild (HÍ) Faculty of Physical Sciences (UI) Raunvísindastofnun (HÍ) Science Institute (UI) |
| Birtist í: | Chemical Communications;51(66) |
| ISSN: | 1359-7345 1364-548X (eISSN) |
| DOI: | 10.1039/C5CC05014F |
| Efnisorð: | Nucleic acid structure; In-cell EPR; Duplex dna; Dynamics perspectives; Distance measurements; Abasic sites; Probe; Spectroscopy; Noncovalent; Kjarnsýrur; Litrófsgreining; DNA-rannsóknir |
| URI: | https://hdl.handle.net/20.500.11815/1957 |
Tilvitnun:Saha, S., Jagtap, A. P., & Sigurdsson, S. T. (2015). Site-directed spin labeling of 2′-amino groups in RNA with isoindoline nitroxides that are resistant to reduction. Chemical Communications, 51(66), 13142-13145 doi:10.1039/c5cc05014f
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Útdráttur:Two aromatic isothiocyanates, derived from isoindoline nitroxides, were synthesized and selectively reacted with 2′-amino groups in RNA. The spin labels displayed limited mobility in RNA, making them promising candidates for distance measurements by pulsed EPR. After conjugation to RNA, a tetraethyl isoindoline derivative showed significant stability under reducing conditions.
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Athugasemdir:Post-print (lokagerð höfundar)
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